碳纳米管/纳米金修饰金电极上柔红霉素电化学行为的研究  

Electrochemical Behaviors of Daunorubicin on Carbon Nanotube/Nanogold Modified Gold Electrode

作　　者：胡尚林[1] 郑华[2] 胡劲波[2] 

机构地区：[1]龙岩学院化学与材料学院,福建龙岩364000 [2]北京师范大学化学学院,北京100875

出　　处：《分析科学学报》2011年第2期187-190,共4页Journal of Analytical Science

基　　金：国家自然科学基金(No.20873012)

摘　　要：将碳纳米管与纳米金结合修饰在金电极上制成修饰电极,并用于柔红霉素(DNR)的电化学行为研究和检测。在4.4mmol/L磷酸盐缓冲溶液(pH=5.81)中,DNR在碳纳米管-纳米金/Au电极上有一对灵敏的氧化还原峰。还原峰电流与DNR的浓度在3.2×10-8～1.0×10-6 mol/L和1.0×10-6～2.2×10-5 mol/L呈线性关系。检出限为1.62×10-8 mol/L。用循环伏安法研究体系的电化学行为。电极过程是受吸附控制的准可逆过程。DNR的电极过程为:先得到一个质子生成质子化的DNR,然后质子化的DNR在电极表面上得到一个质子和二个电子发生还原。A carbon nanotube/nanogold modified electrode was prepared,with which the electrochemical behavior and determination of daunorubicin（DNR） were studied.In 4.4 mmol/L K2 HPO4-KH2 PO4 buffer solution（pH=5.81）,a sensitive oxidative-reductive peak of daunorubicin was obtained by cyclic voltammetry.The reductive peak current was proportional to the concentration of daunorubicin over the range of 3.2×10-8～1.0×10-6 mol/L and 1.0×10-6 mol/L～2.2×10-5 mol/L.The detection limit was 1.62×10-8 mol/L.The electrochemical behavior of the system was studied by cyclic voltammetry.The reduction process was quasi-reversible with adsorption characteristic,which could be described as follow：daunorubicin first got one proton to form protonated daunorubicin（PDNR）;thereafter PDNR got another proton and two electrons,and was thus reduced.

关 键 词：柔红霉素 碳纳米管 纳米金 电化学行为 

分 类 号：O657.15[理学—分析化学]