首发未服药抑郁症静息态默认网络研究  

Altered Brain Activity of Default-mode Network in First-episode, Treatment-naive Major Depressive Disorder

作　　者：朱雪玲[1,2] 王湘[1] 肖晶[1] 廖坚[3] 姚树桥[1] 

机构地区：[1]中南大学湘雅二医院医学心理学研究所,湖南长沙410011 [2]国防科学技术大学人文与社会科学学院,湖南长沙410074 [3]中南大学湘雅三医院影像科

出　　处：《中国临床心理学杂志》2011年第2期146-148,共3页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金(3067070930700236)

摘　　要：目的:分析首发未治疗抑郁症患者静息态默认网络功能改变。方法:采用独立成分分析方法,对25例首发抑郁症患者与25名正常被试进行静息态功能磁共振数据处理,并依据空间最匹配原则对缺省模式网络的独立成分进行挑选,分析患者默认网络的改变。结果:与正常对照比较,抑郁症患者的默认网络呈现前部升高后部降低的模式:即背部额内侧回、腹部额内侧回和腹部前扣带回功能连接升高,楔前叶和后扣带回、角回功能连接减低。结论:静息态下抑郁症默认网络存在广泛的异常。Objective： The aim of the present study was to explore resting-state DMN in first-episode,treatment-naive young adults with major depressive disorder（MDD） and in healthy controls.Methods： The resting-state fMRI data from 25（10 male and 15 female） first-episode,treatment-naive young adults with MDD and 25 age-,gender-and education-matched healthy controls were analysed by independent component analysis（ICA）.Results： A dissociation patterns was presented of anterior and posterior functional connectivity within resting-state default-mode network in first-episode,treatment-naive young adults with major depression.Compared with healthy controls,increased functional connectivity in anterior medial cortex（especially the medial prefrontal cortex（MPFC） and anterior cingulate cortex（ACC）） and decreased functional connectivity in posterior medial cortex（especially the posterior cingulate cortex/precuneus（PCC/precuneus）） and angular gyrus were observed in MD.Conclusion： Such results provide new evidence that DMN is widely affected in MDD and suggest that the abnormal activity of the DMN may be a trait for MDD patients.

关 键 词：抑郁症 默认网络 磁共振成像 冗思 

分 类 号：R395.2[哲学宗教—心理学]