小剂量布地奈德联合优喘平治疗支气管哮喘的临床观察  

Clinical Observation of Budesonide Combined with Protheo in the Treatment of Bronchial Asthma

作　　者：缪胜菊[1] 马杰军[1] 

机构地区：[1]湖北省新华医院急诊科,武汉市430015

出　　处：《中国药房》2011年第16期1486-1487,共2页China Pharmacy

摘　　要：目的:观察小剂量布地奈德联合优喘平治疗支气管哮喘的疗效。方法:将符合支气管哮喘诊断标准的44例患者随机分为对照组和观察组,各22例。对照组使用大剂量布地奈德(600～1600μg·d-1),观察组使用小剂量布地奈德(200～400μg·d-1)联合优喘平(400mg·d-1)治疗。比较2组哮喘控制评分、峰值呼气流速(PEF)占预计值百分比、肺功能(FEV1)占预计值百分比及不良反应发生率。结果:观察组治疗8周后哮喘症状评分优于对照组(P<0.05);PEF占预计值百分比、FEV1占预计值百分比及不良反应发生率与对照组比较均无显著性差异(P>0.05)。结论:小剂量布地奈德联合优喘平治疗哮喘与大剂量布地奈德的疗效相同,不良反应发生率也相同。OBJECTIVE：To observe the clinical efficacy of small doses of budesonide combined with protheo in the treatment of bronchial asthma.METHODS：44 cases of bronchus asthma in accordance with diagnostic criteria were randomly divided into control group and observation group,each group of 22 cases.Control group was given large dose of budesonide（600～1 600 μg·d-1）,and observation group was given small dose of budesonide（200～400 μg·d-1） and protheo（400 mg·d-1）.The asthma control score,proportion of PEF to expected value,percentage of FEV1 to expected value and the incidence of ADR were compared between two groups.RESULTS：The asthma symptoms score of observation group was better than that of control group after 8 weeks of treatment（P0.05）.There was no significant difference in the proportion of PEF to expected value,the percentage of FEV1 to expected value and the incidence of ADR（P0.05）.CONCLUSION：Curative effect and incidence of ADR of small dose of budesonide combined with protheo is similar to that of high dose of budesonide in the treatment of asthma.

关 键 词：布地奈德 优喘平 哮喘 

分 类 号：R562.2[医药卫生—呼吸系统]