冠心病患者血清尿酸、高敏C反应蛋白、纤维蛋白原水平变化的临床研究  

Clinical study on the changes of serum uric acid,high-sensitivity C-reactive protein and fibrinogen in patients with coronary heart disease

作　　者：邵平扬[1] 

机构地区：[1]浙江省嘉兴市第二医院检验科,浙江嘉兴314000

出　　处：《中国卫生检验杂志》2011年第3期673-674,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:研究冠心病(CHD)患者血清尿酸(UA)、高敏C反应蛋白(CRP)及纤维蛋白原(FBG)水平变化及它们之间的关系。方法:分别采用比浊法、终点法测定200例不同类型的CHD患者(稳定型心绞痛(SAP)31例、不稳定型心绞痛(UAP)56例、急性心肌梗死(AMI)113例)以及70例正常患者(对照组)血清UA、CRP及FBG含量。结果:CHD患者组UA([479.84±99.97)μmol/L]、CRP([16.49±4.27)mg/L]和FBG([4.76±0.94)g/L]含量明显高于对照组,差异有统计学意义(P<0.01);CHD患者组中血清UA、CRP及FBG的浓度均以AMI组增高最为显著;CRP同FBG呈正相关(r=0.789,P<0.01)。结论:血清UA、CRP及FBG同CHD关系密切,CRP同FBG呈正相关。Objective：To study the changes of serum uric acid（UA）,high sensitivity C-reactive protein（CRP） and fibrinogen（FBG） levels in patients with coronary heart disease（CHD） and their relationship.Methods：Levels of serum UA,CRP and FBG in 200 CHD patients（31 stable angina pectoris（SAP） patients,56 unstable angina pectoris（UAP） patients and 113 acute myocardial infarction（AMI） patients） were measured and compared with 70 normal patients（control group） by turbidimetry and end point method respectively.Results：The levels of UA（（479.84±99.97）μmol/L）,CRP（（16.49±4.27）mg/L） and FBG（（4.76±0.94）g/L） were significantly higher in CHD group than those in healthy control group（P0.01）,and were greatly increased in AMI group compared with other CHD cases.There was a positive correlation between CRP and FBG（r=0.789,P0.01）.Conclusion：Serum UA,CRP and FBG are highly correlated with CHD.CRP is positively correlated with FBG.

关 键 词：冠心病 尿酸 高敏C反应蛋白 纤维蛋白原 

分 类 号：R541.4[医药卫生—心血管疾病]