连二亚硫酸钠引发的手性2-取代-4-戊烯酸的氟烷基化反应研究  

Fluoroalkylation of Chiral Enoic Acids Initiated by Sodium Dithionite

作　　者：杨雪艳[1] 吕铁梅[1] 朱胜杰[1] 吴范宏[2,3] 

机构地区：[1]华东理工大学化学与分子工程学院,上海200237 [2]上海应用技术学院化学与环境工程学院,上海200235 [3]中国科学院上海有机化学研究所有机氟化学重点实验室,上海200032

出　　处：《化学学报》2011年第7期815-820,共6页Acta Chimica Sinica

摘　　要：研究了手性4-戊烯酸衍生物的氟烷基化反应.以连二亚硫酸钠为引发剂,在碱作用下,乙腈水溶液中手性4-戊烯酸与含氟碘代烷一锅法反应得到手性含氟γ-丁内酯.其结构经核磁共振、高分辨质谱、红外光谱确定.其绝对构型经单晶衍射确定.The fluoroalkylation reaction of chiral 4-pentenoic acids with RFI was investigated. In aqeous acetonitrile, chiral 4-pentenoic acids reacted with fluoroalkyl iodide initiated by sodium dithitionite in the presence of base to afford chiral fluorine-containing y-butyrolactones. The structures of the compounds were comfirmed by NMR, IR, and HRMS techniques. The configurations were ascertained by X-ray single crystal diffraction.

关 键 词：手性烯酸 氟烷基化 连二亚硫酸钠 手性含氟内酯 

分 类 号：O621.25[理学—有机化学]