阻断肾素-血管紧张素-醛固酮系统对自发性高血压大鼠心肌胶原的影响  

Changes of Collagen in the Left Ventricular Myocardium after the Blockage of the Renin Angiotensin Aldosterone System at Different Sites

作　　者：胡英[1,2] 蔡乃绳[1,2] 沈学东[1,2] 杨英珍[1,2] 陈灏珠[1,2] 

机构地区：[1]上海医科大学中山医院心内科 [2]上海市心血管病研究所

出　　处：《上海医科大学学报》1999年第4期268-270,共3页Journal of Fudan University(Medical Science)

基　　金：国家教委博士点基金

摘　　要：目的观察阻断肾素－血管紧张素－醛固酮系统不同环节对高血压心肌纤维化的逆转作用。方法对１５只２６周龄自发性高血压大鼠（ＳＨＲ）分别采用苯那普利、氯沙坦、安体舒通治疗１２周，观察治疗前后大鼠血压、心肌胶原含量及Ⅰ型、Ⅲ型胶原容积分数的变化。另取２６、３８周龄Ｗｉｓｔａｒ大鼠各５只，和２６、３８周龄未做任何治疗的ＳＨＲ各５只作为对照。结果ＳＨＲ－２６和ＳＨＲ－３８组的血压、胶原含量及Ⅰ型、Ⅲ型胶原容积分数均高于同龄Ｗｉｓｔａｒ大鼠组（Ｐ＜０．０５）。苯那普利、氯沙坦治疗后，血压胶原含量及Ⅰ型、Ⅲ型胶原容积分数均较未治疗的ＳＨＲ－３８组明显下降（Ｐ＜０．０５）。安体舒通治疗组血压无明显下降，而胶原含量及Ⅰ型、Ⅲ型胶原容积分数仍明显降低（Ｐ＜０．０５）。结论ＡＣＥＩ、ＡｇＩＩ－ＡＴ１阻断剂能很好降低血压，减轻心肌间质的胶原堆积。而安体舒通虽未能很好降压，但也能减轻心肌胶原的堆积。Purpose To observe the effect of blockage of the renin angiotensin aldosterone system at different sites on the regression of left ventricular fibrosis in spontaneously hypertensive rats (SHR). Methods Fifteen SHR at 26 weeks were treated for 12 weeks by benazapril,losartan or spironolactone.Myocardial collagen content and the collagen volume fraction(CVF) both of type Ⅰ and type Ⅲ was measured before and after the treatment.Ten Wistar rats (5 at 26 weeks,5 at 38 weeks) and 10 untreated SHR( 5 at 26 weeks and 5 at 38 weeks) were served as controls. Results Blood pressure,collagen content and CVF were all higher in the SHR than in Wistar rats at 26 weeks and 38 weeks old.Benazapril and losartan treatment could reduce blood pressure,collagen content and CVF of the SHR ( P <0.05),but spironolactone could only reduce collagen content (P <0.05) and CVF ( P <0.05) without the reduction of blood pressure. Conclusions Administration of ACEI and AgIIAT1 antagonist can reduce blood pressure,but spironolactone treatment can not.All of the three drugs we used have the same effects on the fibrosis regression.

关 键 词：高血压 大鼠 左室肥厚 RAAS 心肌胶原 

分 类 号：R544.106[医药卫生—心血管疾病] R541.902[医药卫生—内科学]