Clinical Observations on the Dose-effect Relationship of Gegen Qin Lian Decoction (葛根芩连汤) on 54 Out-patients with Type 2 Diabetes  

作　　者：仝小林 赵林华 连凤梅 周强 夏乐 张家成 陈欣燕 姬航宇 

机构地区：[1]Guang' anmen Hospital, China Academy of Chinese Medical Sciences [2]Beijing University of Chinese Medicine

出　　处：《Journal of Traditional Chinese Medicine》2011年第1期56-59,共4页中医杂志（英文版）

基　　金：supported by a grant from the National Basic Research Program (973 Program, No.2010CB530601)

摘　　要：Objective: To observe the therapeutic effect of different dosages of Gegen Qin Lian Decoction (葛根芩连汤) on type 2 diabetic patients. Methods: Fifty-four type 2 diabetic patients from low dosage group (20 cases), medium dosage group (19 cases) and high dosage group (15 cases) were treated with different dosage of Gegen Qin Lian Decoction for 12 weeks. Fasting blood-glucose (FBG), postprandial blood sugar (PBG) and Hemoglobin A1c (HbAlc) were determined before and after treatment. Results: With the increase of dosage, the overall effective rate of glycaemic control increased, and FBG, PBG, HbAlc decreased. The overall effective rate of blood glucose control of high dosage, medium dosage and low dosage group were 80%, 47%, 30% respectively, and there were significant differences between high dosage group and low dosage group. The decrease of FBG, PBG and HbAlc of high dosage showed significant differences from low dosage too. These data was analyzed by trend χ2 test and covariance analysis. Conclusion: The result indicated that different dosage of Gegen Qin Lian Decoction has dose-effect relationship in reducing HbAlc and FBG.Objective： To observe the therapeutic effect of different dosages of Gegen Qin Lian Decoction （葛根芩连汤） on type 2 diabetic patients. Methods： Fifty-four type 2 diabetic patients from low dosage group （20 cases）, medium dosage group （19 cases） and high dosage group （15 cases） were treated with different dosage of Gegen Qin Lian Decoction for 12 weeks. Fasting blood-glucose （FBG）, postprandial blood sugar （PBG） and Hemoglobin A1c （HbAlc） were determined before and after treatment. Results： With the increase of dosage, the overall effective rate of glycaemic control increased, and FBG, PBG, HbAlc decreased. The overall effective rate of blood glucose control of high dosage, medium dosage and low dosage group were 80%, 47%, 30% respectively, and there were significant differences between high dosage group and low dosage group. The decrease of FBG, PBG and HbAlc of high dosage showed significant differences from low dosage too. These data was analyzed by trend χ2 test and covariance analysis. Conclusion： The result indicated that different dosage of Gegen Qin Lian Decoction has dose-effect relationship in reducing HbAlc and FBG.

关 键 词：Gegen Qin Lian Decoction  dose-effect relationship type2 diabetes 

分 类 号：R259[医药卫生—中西医结合]