阿托伐他汀减少冠脉介入治疗引起心肌损伤及炎性反应的临床观察  

Clinical observation of Atorvastatin to reduce myocardial injury and the inflammatory response induced by coronary intervention

作　　者：刘红军[1] 

机构地区：[1]新乡市中心医院,河南453000

出　　处：《当代医学》2011年第5期97-99,共3页Contemporary Medicine

摘　　要：目的探讨经皮冠状动脉介入治疗(PCI)前给予阿托伐他汀预治疗能否减轻PCI相关炎症反应及心肌损伤。方法 78例拟行PCI的不稳定型心绞痛患者随机分为阿托伐他汀预治疗组(42例)和对照组(36例)。治疗组在PCI前接受7d的阿托伐他汀40mg/d的治疗;对照组在PCI前不使用他汀类药物。两组患者均接受其他常规治疗,且在PCI后均接受他汀类药物治疗。在术前和术后24h检测超敏C反应蛋白(hs-CRP)、髓过氧化物酶(MPO)、肌钙蛋白Ⅰ型(cTnI),并记录围术期心肌梗死的发生率。结果治疗组和对照组的术后hs-CRP、MPO、cTnI与术前比较均有显著升高(t=8.2707,3.5621,2.6705和3.1671,3.8826,2.4049,P<0.01或P<0.05);治疗组术前和术后的hs-CRP、MPO、cTnI均较对照组显著降低(t=3.3525,2.1587,2.8529和3.1171,2.7133,2.0915,P<0.01或P<0.05);治疗组的围术期心肌梗死发生率显著低于对照组(x2=4.3858,P<0.05)。结论 PCI前给予阿托伐他汀40 mg/d预防性28d治疗,可以显著减少PCI造成的炎症反应及心肌损伤,对心肌有保护作用,安全性好。Objective To evaluate the meaning of Atorvastatin to reduce PCI-related inflammatory response and myocardial injury. Methods： 78 patients scheduled for PCI, unstable angina were randomly assigned to atorvastatin pre-treatment group （42 cases） and control group （36 cases）. PCI treatment group received 7 d before the atorvastatin 40 mg / d treatment; the control group before PCI does not use statins. All patients received other conventional treatments, and are accepted in the post-PCI statin therapy. 24h before and after surgery in the detection of high sensitivity C-reactive protein （hs-CRP）, myeloperoxidase （MPO）, cardiac troponin I type （cTnI）, and record the perioperative incidence of myocardial infarction. Results： The treatment group and control group after hs-CRP, MPO, cTnI compared with preoperative increased significantly （t=8.2707,3.5621,2.6705 and 3.1671,3.8826,2.4049, P〈0.01 or P〈0.05）; Treatment group before and after surgery of hs-CRP, MPO, cTnI was significantly lower than control group （t=3.3525,2.1587,2.8529 and 3.1171,2.7133,2.0915, P〈0.01 or P〈0.05）; treatment group during the perioperative The incidence of myocardial infarction was significantly lower than the control group （x2=4.3858, P〈0.05）. Conclusion PCI ago given atorvastatin 40 mg / d 28d preventive treatment can significantly reduce the inflammation caused by PCI and myocardial injury, cardioprotective effect, security is good.

关 键 词：不稳定型心绞痛 经皮冠状动脉介入 阿托伐他汀 心肌保护 抗炎作用 

分 类 号：R541.4[医药卫生—心血管疾病]