同心管微通道内固体脂质纳米粒的制备与传质  

Formation of solid lipid nanoparticles and its mass transfer mechanisms in axle dual microchannels

作　　者：张颂红[1,2] 贠军贤[2] 沈绍传[2] 陈卓[2] 姚克俭[2] 陈纪忠[1] 

机构地区：[1]浙江大学材料与化学工程学系,浙江杭州310027 [2]浙江工业大学化学工程与材料学院,绿色合成技术国家重点实验室培育基地,浙江杭州310032

出　　处：《浙江大学学报（工学版）》2011年第3期544-550,共7页Journal of Zhejiang University：Engineering Science

基　　金：国家自然科学基金资助项目(20606031)

摘　　要：研究利用同心管微通道制备固体脂质纳米粒(SLNs),即借助外管长内管短的同心管微通道提供脂相和水相,当两相在外管中相遇时,由于溶剂间的快速相互扩散,使脂相中脂质体达到过饱和而生成SLNs.将结果与注射法对比,并考察同心管管径及弹状流对颗粒制备的影响.根据高速摄像拍摄的两相流场分布特点,对两相间的扩散传质及SLNs成形进行初步分析.结果表明:用同心管法可制备得到粒径小(100～350nm)、分布均匀(多分散性指数小于0.25)的SLNs;与注射法相比,该方法所得颗粒粒径更小,但分布范围略宽;同心管内管内径越小,所得SLNs平均粒径越小;引入弹状流后,SLNs粒径分布变化不大,但可较好地缓解微通道内的堵塞现象;两相间传质过程可以用稳态层流传质模型近似描述.Solid lipid nanoparticles（SLNs） preparation in axle dual microchannels was studied.A lipid phase and a liquid phase were created respectively by axle dual microchannels which had a shorter inner tube and a longer outer tube.When two phases met in the outer tube,solvents diffused quickly into the other phase,which led to the supersaturation of lipid and the formation of SLNs.The method was compared with the reported solvent injection method,and effects of microchannel dimension and slug flow on the formation of SLNs were studied.The process of mass transfer and the formation of SLNs were analysed based on the flow field distribution captured by CCD.The results show that SLNs with small size（100-350 nm） and narrow distribution（polydispersity less than 0.25） can be prepared successfully.Comparing with the reported solvent injection method,the mean diameter of SLNs prepared by this method is smaller but the distribution is a little wilder.Under the same conditions,the smaller the inner tube is,the smaller SLNs will be prepared.The slug flow in the outer tube has little inflection on the distribution of SLNs,however,it could alleviate the flow jam obviously.The results also show that the laminar flow steady-state model could explicate the mass transfer model of stable laminar flow process in the microchannel approximatively.

关 键 词：固体脂质纳米粒 微通道 粒径分布 传质机理 

分 类 号：TQ026.9[化学工程]