溴代环丙烷与酰胺在Ullmann反应条件下的反应研究  

Study on the Reaction of Bromocyclopropane with Amide under Conditions of Ullmann Reaction

作　　者：冯乙巳[1] 高铁军[1] 齐洪侠[1] 叶加久[1] 许华建[1] 

机构地区：[1]合肥工业大学化学工程学院,合肥230009

出　　处：《化学通报》2011年第4期362-367,共6页Chemistry

基　　金：国家自然科学基金项目(20802015)资助

摘　　要：在某些情况下,三元环的性质与烯基的CC双键相似,而烯基溴代物已被广泛应用于Ullmann反应,因此,本文考察了1-溴-2-苯基环丙烷与酰胺在Ullmann条件下的反应情况。结果显示,在此反应条件下,环丙烷结构发生了开环,开环后的产物会发生双分子偶联;当在体系中加入亲核体时,开环的物质同时会与亲核体发生偶联反应,反应效率中等。The properties of three-membered ring are of ten as same as those of C C.Alkenyl bromides have been widely applied in the Ullmann reaction.In this paper the reaction of 1-bromo-2-phenylcyclopropane with amide was investigated under the conditions of Ullmann reaction.The results showed the ring structure of cyclopropane would be opened and the two-molecule coupling be happened.The ring-opened intermediate was able to couple with nucleophilic agent in moderate yield when it was added to the reaction system.

关 键 词：ULLMANN反应 1-溴-2-苯基环丙烷 开环 偶联反应 

分 类 号：O621.25[理学—有机化学]