PMS肝气逆证诊断实验室参考指标的建立  

To Establishing Laboratory Referenced Indexes of Diagnoses of Premenstrual Syndrome of Invasion of the Hyperactive Liver-qi

作　　者：高冬梅[1] 乔明琦[1] 张惠云[1] 

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《辽宁中医杂志》2011年第4期618-621,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：科技部十五攻关资助课题(2004BA721A04)

摘　　要：目的:建立PMS肝气逆证实验室检测参考指标和判定参考值,揭示其部分微观机制。方法:全国7家单位联合进行流行病学调查,观察受试者和患者血清中微观指标变化,分别采用放射免疫法检测性激素和高效液相法检测单胺类神经递质。结果:肝气逆证组较正常对照组,E2、P在月经周期3个不同时期均有降低(P<0.05),PRL、5-HT、NE显著升高(P<0.01)。结论:PMS肝气逆证E2排卵期分泌峰低平与黄体期E2、P分泌峰阙如及PRL、5-HT、NE升高是PMS肝气逆证发病深层机制之一,E2、P、PRL、5-HT、NE是反映PMS肝气逆证诊断的实验室参考指标。Objective：To establish laboratory referenced indexes and determinant referenced value of diagnoses of premenstrual syndrome（PMS） of invasion of the hyperactive Liver-qi,and to open out part microcosmic mechanism of PMS of invasion of the hyperactive Liver-qi.Methods：Countrywide seven research units carried through epidemiology prospective to observe estrogen and neurotransmitter in the blood in the receivers and patients,respectively adopted radioimmunoassay and HPLC method to detect them.Results：Compared to control group,the levels of serum estradiol（E2） and progesterone（P） in the three different menstrual cycle were decresed（P0.05）,the levels of serum prolactin（PRL）、5-serotonin（5-HT）、and norepinephrine（NE） were significantly increased（P0.01）.Conclusion：The levels of serum E2 in the ovulation period was decresed,the levels of serum E2 and P in the luteal phase were decreased,and PRL、5-HT、NE were increased in the patiants,which were deep-seated microcosmic mechanism of PMS of invasion of the hyperactive Liver-qi.

关 键 词：经前期综合征 雌激素 单胺类神经递质/血清 肝气逆证 

分 类 号：R271.115[医药卫生—中医妇科学]