神经生长因子及其受体在自然流产绒毛组织中表达的研究  

Expression of nerve growth factor and its receptors in villi of early pregnant women with spontaneous abortion

作　　者：张果果[1] 陈虹[1] 

机构地区：[1]贵州省贵阳医学院附属医院,550004

出　　处：《中国计划生育学杂志》2011年第4期206-209,共4页Chinese Journal of Family Planning

摘　　要：目的:通过测定神经生长因子(NGF)及其受体在早期自然流产和正常早孕者绒毛组织中的表达情况,探讨其临床意义。方法:收集自然流产者30例作为研究组和正常早孕人工流产者30例作为对照组,采用两步法原位杂交免疫组化方法检测两组对象绒毛组织中NGF及其受体高亲和型酪氨酸蛋白激酶类受体(TrkA)和P75的表达差异。结果:P75在绒毛组织染色阳性标本中的平均染色分值研究组高于对照组(P<0.05);NGF及其受体TrkA在绒毛组织染色阳性标本中的平均染色分值研究组低于对照组(P<0.05)。结论:NGF及其受体TrkA,P75在自然流产绒毛组织中异常表达可能与自然流产的发病机理有关。Objective：To analyze the effect of nerve growth factor（NGF）and its receptors TrkA,P75 on early spontaneous abortion.Methods：Immunohistochemical analysis was used to determine expressions of NGF and its receptors TrkA,P75 in villi of early pregnant women with spontaneous abortion（n=30）.Thirty women who underwent induced abortion served as the control.Results：In the positive-staining villi,the mean staining sore of P75 in the study group was significantly higher（P0.05）,while those of NGF and TrkA were significantly lower（P0.05）.Conclusion：The abnormal expression of NGF and its receptors TrkA,P75 in villi maybe involved in the pathogenesis of early spontaneous abortion.

关 键 词：神经生长因子 型酪氨酸蛋白激酶类受体 自然流产 绒毛组织 

分 类 号：R714.21[医药卫生—妇产科学]