苦荞萌发物对大鼠腹腔肥大细胞组胺释放的影响  

Effects of Germination Extract of Tartary Buckwheat on Histamine Release from Rats Peritoneal Mast Cells

作　　者：周小理[1] 杨延利[2] 王青[1] 李宗杰[1] 

机构地区：[1]上海应用技术学院,香料香精技术与工程学院,上海200235 [2]上海师范大学,生命与环境科学学院,上海200234

出　　处：《食品工业》2011年第4期12-14,共3页The Food Industry

基　　金：国家自然科学基本项目(31071527)

摘　　要：以苦荞萌发物——苦荞芽粉的乙醇提取物为原料,采用啮齿动物实验模型对其抗过敏活性进行研究。通过制备Wistar大鼠腹腔肥大细胞悬液,检测不同萌发天数苦荞芽粉的乙醇提取物对组胺释放的影响。试验结果表明:苦荞芽粉的乙醇提取物对化合物(Compound 48/80)引起的大鼠腹腔肥大细胞的组胺释放均有抑制作用,且抑制率高于苦荞种子的乙醇提取物。其中,以萌发3 d的苦荞芽粉的抑制效果最好。芦丁和槲皮素对组胺释放均有抑制作用,且槲皮素对组胺释放的抑制作用强于芦丁。This paper investigated the effect of tartary buckwheat germination extract（TBGE） on anti-allergic reaction of the rodent experimental models.The extracted Wistar rat peritoneal mast cells（R/MINC） in vitro was used to test the effects of TBGE with different germinating period from 0~5 d on histamine releasing.Results showed that the TBGEs could inhibit the release of histamine from R/MINC responded to Compound 48/80.This effect of inhibition of TBGEs was much higher than the extracts from seeds,and among these TBGEs,the 3 d greminated sprouts had the highest inhibition effect.Rutin and quercetin both manifested the antihistamine effect.And compared with rutin,quercetin had a higher synergistic effect.

关 键 词：苦荞 萌发 肥大细胞 组胺释放 

分 类 号：R285.5[医药卫生—中药学]