急性冠脉综合征中性粒细胞弹性蛋白酶浓度在他仃类药物干预下的变化研究  

ALTERATION OF THE CONCENTRATION OF PLASMA NEUTROPHIL ELASTASE IN PATIENTS WITH ACUTE CORONARY SYNDROME UNDERGONE FLUVASTATIN

作　　者：林云[1] 姚震[1] 顾申红[1] 杨新玮[1] 张光星[1] 崔开媚[1] 

机构地区：[1]海南医学院附属医院心内科,海口570102

出　　处：《现代预防医学》2011年第8期1597-1598,F0003,共3页Modern Preventive Medicine

摘　　要：[目的]研究他仃类药物对急性冠脉综合征(ACS)血浆患者中性粒细胞弹性蛋白酶(Neutrophil elastaseNE)的影响。[方法]将91名冠心病患者分成4组:(1)急性心肌梗死组(AMI组)45例,(2)不稳定型心绞痛组(UAP组)18例,(3)稳定型心绞痛组(SAP组)13例,(4)陈旧性心肌梗死组(OMI组)15例,AMI组和UAP组合并为ACS组,为冠脉急性病变(A组);SAP组和OMI组合为慢性冠脉病变(B组),两组同时给予氟伐他仃胶囊。患者在入组时、服药后1周、第1月、第12月内抽取静脉血,PMN Elastase Kit试剂盒以酶联免疫吸附检测法(ELISA)检测患者血浆中NE浓度。同时观察患者在12个月内心绞痛发病率和其他心血管事件发生率。[结果](1)A组和B组在入组时所测得的NE浓度的差异有统计学意义(H=34.503,P﹤0.000 1),(2)给予氟伐他汀干预后,发现A组所测得的NE浓度的差异在不同时期比较有统计学意义(χ2=13.537,P﹤0.05);B组所测得的NE浓度的差异在不同时期比较无统计学意义(χ2=2.523,P﹥0.05),(3)A组和B组在应用氟伐他汀治疗1年,心绞痛和其他心血管事件发生率均较低,两组比较差异无统计意义(P﹥0.05)。[结论]血浆NE浓度与急性冠脉综合症有相关性。在氟伐他仃的干预下,血浆NE浓度在急性病程不同时段里变化差异有统计学意义,在慢性病程中变化不大;再次发生心绞痛和其他心血管事件发病率下降,两组差异无统计学意义,进一步证实氟伐他仃可以减少心绞痛和其他心血管事件发病率。[Objective]To investigate the effect of fluvastatin on the concentration of plasma neutrophil elastase（NE）in patients with ACS.[Methods]Ninety-one subjects were divided into four groups：（1）acute myocardial infarction group（AMI,n=45）;（2）unstable angina pectoris group（UAP,n=18）;（3）stable angina pectoris group（SAP,n=13）;（4）old myocardial infarction group（OMI,n=15）.The AMI and UAP group were combined to ACS group（group A）;The SAP and OMI group were combined to coronary artery stable group（group B）.The concentration of plasma NE was detected by ELISA method before and at one-week,one-month and one-year after taking 40 mg fluvastatin each night.The incidence of angina and other cardiovascular events were also observed during the period.[Results]There was statistic difference in the baseline value of plasma NE between group A and group B（H=34.503,P﹤0.000 1）.The concentration of plasma NE in group A showed statistic difference in different time（χ^2 = 13.537,P﹤ 0.05）,while no difference was found in group B（χ^2 = 2.523,P﹥0.05）.The incidence of angina and other cardiovascular events were low,signifcant difference between the two group was not found during one-year treatment with fluvastatin（P﹥0.05）.[Conclusion]The fluvastatin can decrease the concentration of plasma NE in patients with ACS,and reduce the incidence of angina and other cardiovascular events.

关 键 词：急性冠脉综合症 中性粒细胞 他仃类药物 

分 类 号：R541.4[医药卫生—心血管疾病]