新旧工艺仙灵骨葆胶囊中补骨脂大鼠肠吸收特性对比研究  

Comparative study of absorption kinetics in intestines of rats on Xianlinggubao capsule prepared by different technologies

作　　者：武慧超[1] 杜守颖[1] 陆洋[1] 陈雯[2] 马勇[1] 李鹏跃[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]中国中医科学院广安门医院,北京100053

出　　处：《中国中药杂志》2011年第8期992-996,共5页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09502-008;2009ZX09308-003)

摘　　要：目的:研究新型仙灵骨葆胶囊中补骨脂有效成分补骨脂素和异补骨脂素的大鼠肠吸收特性,并与仙灵骨葆胶囊肠吸收结果进行对比。方法:采用大鼠离体非翻转肠囊法,以HPLC对补骨脂素和异补骨脂素进行检测,研究吸收部位和药物浓度对补骨脂素和异补骨脂素肠吸收的影响。结果:补骨脂素和异补骨脂素在十二指肠的吸收略好于空肠和回肠;低浓度和中浓度胶囊内容物中补骨脂素、异补骨脂素Ka无显著性差异,但高浓度内容物Ka显著减小(P<0.05)。结论:胶囊内容物溶出速度可能影响补骨脂素和异补骨脂素的肠吸收;新工艺仙灵骨葆胶囊中补骨脂素和异补骨脂素的肠吸收均明显好于原工艺,表明新工艺仙灵骨葆胶囊中补骨脂有效成分更易吸收。Objective： To study the characteristics of intestinal absorption of psoralen and isopsoralen of Xianlinggubao capsule, and compare the absorption of Xianlinggubao capsule prepared by different technologies. Method ： Non everted gut sac method was applied to investigate the influence of absorption sites and drug concentration on psoralen and isopsoralen absorption, which were determined by HPLC. Result： Although the absorption rate constants of psoralen and isopsoralen in duodenum were more than that in jejunum and ileum, there was no significance difference between them. The absorption rate constants of psoralen kept at the same level when the concentrations of drug solution were at middle and low level, while the absorption rate constant at high level was absolutely lower than them（ P 〈 0. 05 ）. The results of isopsoralen were the same as psoralen＇s. Conclusion： Intestinal absorption of psoralen and isopsoralen may be affected by the dissolution. The absorption rate constants of psoralen and isopsoralen in new Xianlinggubao capsules are higher. The absorptions of active components absorption has significant difference in different preparation processes of Xianlinggubao capsule.

关 键 词：仙灵骨葆胶囊 非翻转肠囊法 补骨脂素 异补骨脂素 HPLC 

分 类 号：R285.5[医药卫生—中药学]