白术炮制工艺及炮制原理的研究  

Study on processing technology and processing principles of Atractrylodis Macrocephalae Rhizoma

作　　者：容穗华[1] 林海[1] 高妮[2] 

机构地区：[1]广东省中医院,广东广州510120 [2]广州市医药职业学校,广东广州510430

出　　处：《中国中药杂志》2011年第8期1001-1003,共3页China Journal of Chinese Materia Medica

摘　　要：目的:研究白术炮制前后有效成分的变化规律,探索白术炮制原理。方法:采用HPLC测定白术不同炮制品中苍术酮、白术内酯Ⅰ、白术内酯Ⅲ、白术内酯Ⅱ的含量,对其总挥发油含量也进行测定,探索其炮制前后含量变化规律。结果:与生品比较,不同的炮制品中苍术酮的含量均有不同程度的降低,其中土炒白术的含量降低最多,其质量分数为0.33%,降低了25%;白术内酯Ⅰ和白术内酯Ⅲ的含量则显著升高,以麸炒白术中两者的质量分数最高,分别为0.069%,0.078%;而白术内酯Ⅱ的含量略有升高,以土炒白术的含量最高,为0.066%;总挥发油的含量显著降低,以土炒白术的含量最低,仅为0.64%。结论:白术经炮制后苍术酮转化为白术内酯Ⅰ,Ⅱ,Ⅲ等内酯类成分,苍术酮的含量降低,燥性缓和,白术内酯类含量增加,健脾的作用增强。Objective： To investigate the rule about changes on main active compositions of Atraetrylodis Macrocephalae Rhizoma before and after being processed, and to explore its processing principle. Method： The HPLC method was employed to determine the content of atractrylone, atractrylode Ⅰ,Ⅱ,Ⅲ and total volatile oil of Atractrylodis Macrocephalae Rhizoma with different processes. The processing principle before and after processing of Atractrylodis Macroeephalae Rhizoma was investigated. Result： Compared with Atractrylodis Macrocephalae Rhizoma, the contents of atractrylone in different processed products of Atractrylodis Macrocephalae Rhizoma were decreased by some extent. The lowest content was 0.33% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt, reduced by 25.4% ;the content of atractylenolide Ⅰ , Ⅲ were significantly increased, the highest content were 0. 069% and 0.078% in Atractrylodis Macrocephalae Rhizoma of stir-fried with bran, respectively; the content of atractylenolide Ⅱ was increased slightly, the highest content was 0. 066% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt; the content of total volatile oil was significantly reduced, the lowest content was 0.64% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt. Conclusion.. The content of atractylon is significantly reduced after processing, which changed into atractrylode Ⅰ,Ⅱ,Ⅲ by some extent, and improve the effective cure of Atractrylodis Macrocephala Rhizoma.

关 键 词：白术 白术内酯 苍术酮 炮制工艺 HPLC 

分 类 号：R283[医药卫生—中药学]