氨甲酰化促红细胞生成素逆转慢性心力衰竭大鼠左室重构的研究  

Carbamylated erythropoietin reverses left ventricular remodeling in rats with chronic heart failure

作　　者：崔丽君[1] 张丽[1] 谈丽丽[1] 王锋[1] 王志禄[2] 许哲通[3] 李万玲[1] 贾军正[1] 郭文芬[1] 

机构地区：[1]兰州大学第一临床医学院,730000 [2]兰州大学第一医院心内科,730000 [3]河北省保定市第二医院心内科,071051

出　　处：《实用医学杂志》2011年第8期1350-1352,共3页The Journal of Practical Medicine

基　　金：甘肃省新药临床前研究重点实验室开放基金项目(编号:GSKFKT-0707)

摘　　要：目的:探讨氨甲酰化促红细胞生成素(CEPO)对慢性心力衰竭(CHF)大鼠左心室重构的影响。方法:健康雄性Wistar大鼠90只,随机选取10只作为对照组,其余腹腔注射异丙肾上腺素(ISO)进行造模。5周后将造模成功者再分为CHF组和CEPO组,后者腹腔注射CEPO50μg/kg,2次/周,CHF组和对照组同期腹腔注射等量生理盐水,4周后检测各组大鼠血流动力学指标、血浆B型脑钠肽(BNP)水平,并计算左心室重量指数(LVW/BW)。结果:与对照组相比,CHF组左室内压峰值(LVSP)、左室内压上升/下降最大速率(±dp/dtmax)显著降低,左室舒张末压(LVEDP)显著升高(P<0.05),血浆BNP水平显著升高(P<0.05),LVW/BW也显著升高(P<0.05)。与CHF组相比,CEPO组LVSP、±dp/dtmax均显著升高,而LVEDP则显著降低(P<0.05),血浆BNP水平显著降低(P<0.01),LVW/BW也显著降低(P<0.05)。结论:CEPO可通过降低血浆BNP水平、减轻左心室重构来改善CHF大鼠的心功能。Objective To explore the effect of carbamylated erythropoietin on left ventricular remodeling in rats with chronic heart failure （CHF）. Methods 10 of 90 healthy male wistar rats were randomly assigned to control group,the rest received intraperitoneal injections of isoproterenol to establish a model of CHF. After 5 weeks,the survived rats were randomly divided into CHF group and CEPO group.CEPO group was administered intraperitoneal injections of CEPO of 50μg/kg twice a week for 4 weeks;CHF group and the control group received equivalent saline. After the completion of CEPO injection, hemodynamic, level of BNP, and the ratio of left ventricular weight to body weight （LVW/BW） were measured. Results As compared with the control group, left ventricular end systolic pressure （LVSP）, maximal rate of rise/decline of left ventricular pressure （：t：dp/dtmax） were significantly decreased in CHF group（P 〈 0.05）, whereas left ventricular end diastolic pressure （LVEDP）, level of BNP and the ratio of left ventrieular weight to body weight （LVW/BW） were significantly higher （P 〈 0.05）. As compared with CHF group, LVSP and ±dp/dtmax were significantly increased （P 〈 0.05）, while LVEDP, level of BNP, and LVW/BW were significantly decreased （P 〈 0.05） in CEPO group. Conclusions CEPO can improve cardiac function in rats with CHF by reducing BNP level and alleviating cardiac remodeling.

关 键 词：慢性心力衰竭 氨甲酰化促红细胞生成素 B型脑钠肽 心室重构 

分 类 号：R541.6[医药卫生—心血管疾病]