蛋白磷酸酶2A诱导肠上皮细胞凋亡机制研究进展  

Advances in the mechanism of intestinal epithelial cell apoptosis induced by protein phosphatase 2A

作　　者：石忱长[1] 秦环龙[1] 

机构地区：[1]上海交通大学附属第六人民医院普外科,200233

出　　处：《中华临床营养杂志》2011年第2期108-112,共5页Chinese Journal of Clinical Nutrition

基　　金：国家自然科学基金（81070293）

摘　　要：蛋白磷酸酶2A是细胞内重要的丝氨酸／苏氨酸蛋白磷酸酶，通过可逆性磷酸化使已磷酸化的蛋白质脱磷酸，参与细胞内众多信号通路和生理生化过程的调节。其生理活性的改变与肠上皮细胞损伤后凋亡、再生的发生密切相关，可能是肠上皮细胞凋亡与再生达到平衡的一个调节因子。Protein phosphatase 2A （PP2A） is a major Ser/Thr phosphatase involved in several cellular signal transduetion pathways. The reversible phosphorylation of proteins is accomplished by opposing activities of kinases and phosphatases. PP2A controls the specific dephosphorylation of thousands of phosphoprotein substrates and thus regulates physiological and biochemical processes of organism. The changes of the physiological activities Of PP2A closely relate to apoptosis and regeneration of injured intestinal epithelial cell, and PP2A may be a regulatory factor in balancing the apoptosis and regeneration of intestinal epithelial cell.

关 键 词：蛋白磷酸酶2A 肠上皮细胞 凋亡 

分 类 号：R285.5[医药卫生—中药学]