肾素—血管紧张素系统双基因多态性与老年人冠心病慢性心力衰竭的关系  

Relationship Between Renin-Angiotensin System Gene Polymorphism and Ischemic Chronic Heart Failure in Aged Coronary Artery Disease Patient

作　　者：彭健[1] 罗礼云[1] 李铁[2] 梅啸 牛云茜[4] 龚五星[5] 

机构地区：[1]中山大学附属第五医院心内科二区,广东省珠海市519000 [2]中山大学附属第五医院老年病科,广东省珠海市519000 [3]珠海市第二人民医院ICU [4]澳门镜湖医院心脏病科 [5]暨南大学附属第三医院分子生物实验中心

出　　处：《中国循环杂志》2011年第2期93-96,共4页Chinese Circulation Journal

摘　　要：目的:探讨中国南方部分汉族人群的老年冠心病患者中,肾素—血管紧张素系统中的关键成分即血管紧张素转换酶(ACE)及血管紧张素原(AGT)双基因多态性与慢性心力衰竭(心衰)发病的关系。方法:应用聚合酶链反应及限制性片断长度多态性技术,对396例老年冠心病患者的ACE基因插入/缺失(I/D)及AGT基因M235T多态性进行检测。将其中196例合并慢性心衰患者作为病例组,其余200例心功能正常者作为对照组。结果:①病例组DD基因型频率及D等位基因频率均高于对照组;②病例组TT基因型频率及T等位基因频率均高于对照组;③联合分析ACE与AGT基因多态性显示,两组中同时具有DD型ACE基因及TT型AGT基因的频率分别为28.6%及15.0%,前者明显高于后者。结论:DD型ACE基因及TT型AGT基因可能是中国南方部分汉族老年冠心病慢性心衰患者发病的遗传危险因素,ACE和AGT基因在慢性心衰的发生中具有协同作用。Objective：To investigate the relationship between angiotensin-converting enzyme （ACE）gene insertion/deletion （I/D） and angiotensinogen （AGT） gene M235T polymorphism with the onset of ischemic chronic heart failure （CHF） in aged coronary artery disease （CAD） patients in South China. Methods ： A total of 396 consecutive CAD patients with the age of （ 60 - 91 ） years were divided into two groups, CHF group, n = 196, and Control group, n = 200, the patients had stable angina pectoris and with the left ventricular ejection fraction 1〉 45%. Genotype distributions, ACE gene LXD and AGT gene M235T polymorphisms were analyzed by PCR and restriction fragment length polymorphism （RFLP） methods in both groups. Rcsults：（1）The frequencies of DD genotype of ACE gene and D allele of ACE gene were higher in C/IF group than that in Control group respectively. （2）The frequencies of TF genotype and T allele of AGT gene were higher in CHF group than that in Control group. （3）In combined genotype analysis, the genotype of DD in ACE ＋ TT in AGT was significantly higher in CHF group than that in Control group （28.6% vs. 15.0% ）. Conclusion ： ACE gene I/D polymorphism and AGT gene M235T polymorphisms are related to the onset of ischemic chronic heart failure in aged CAD patients in South China. ACE and AGT gene have an interaction role in the onset of CHF.

关 键 词：血管紧张素转换酶 血管紧张素原 多态性 冠心病 心力衰竭 

分 类 号：R541[医药卫生—心血管疾病]