2型糖尿病患者亚临床动脉粥样硬化与高敏C反应蛋白水平的关系  

Relationship between high sensitivity C-reactive protein and subclinical atherosclerosis in patients with type 2 diabetes

作　　者：宁洁[1,2] 唐炜立[1] 周智广[1] 冯琼[1] 刘玉华[1] 周卫东[1] 刘志文[1] 

机构地区：[1]中南大学湘雅二医院内分泌科中南大学糖尿病中心中南大学代谢内分泌研究所,410011 [2]湖南中医药大学附属湖南省第二人民医院内分泌科

出　　处：《中国心血管杂志》2011年第2期115-117,共3页Chinese Journal of Cardiovascular Medicine

基　　金：国家十五科技攻关项目(2001BA702B01;2001BA702B04)

摘　　要：目的探讨2型糖尿病(T2DM)患者亚临床动脉粥样硬化(SAS)与高敏C反应蛋白(hsCRP)的关系。方法 170例新确诊T2DM患者随访2年后,56例出现SAS,用免疫比浊法测定T2DM伴与不伴SAS患者及健康对照组hsCRP水平。结果伴SAS组hsCRP水平[0.64(0.50～7.07)mg/L]高于不伴SAS组[0.53(0.14～7.44)mg/L,P>0.05],2组均高于健康对照组[0.36(0.10-9.60)mg/L,均为P<0.05];将SAS为因变量,以各危险因素为自变量作Logistic回归分析显示:hsCRP、年龄、三酰甘油进入回归方程(P<0.05)。结论 hsCRP、年龄、三酰甘油可能是T2DM患者SAS发生的独立危险因素。Objective To investigate the relationship between plasma level of high sensitivity C-reactive protein （hsCRP） and subclinical atherosclerosis （SAS） in patients with type 2 diabetes （T2DM）. Methods One hundred and seventy new diagnosed T2DM patients and 56 healthy subjects were enrolled in this study. A written informed consent form was signed by each participant before enrollment. Fifty-six of the 170 T2DM patients were diagnosed as SAS after 2 years of follow-up. Plasma level of hsCRP was measured before enrollment and compared among T2DM patients with or without SAS and healthy control subjects. Risk factors of subclinical atherosclerosis in 170 T2DM patients were analyzed by using Logistic regression analysis. Results Plasma HsCRP level in T2DM patients with SAS was higher [ 0. 64 （0. 50-7.07 ） mg/L] than without [0. 53 （0. 14-7. 44） mg/L]. T2DM patients with or without SAS had higher plasma HsCRP level than healthy control subjects[0. 36（0. 10-9. 60） mg/L]. Logistic analysis showed that SAS was closely correlated with hsCRP, TG and age （all P 〈 0. 05 ）. Conclusions Our findings demonstrate that plasma hsCRP is an independent risk factor of SAS in patients with T2DM.

关 键 词：糖尿病 2型 动脉粥样硬化 C反应蛋白质 

分 类 号：R587.1[医药卫生—内分泌] R543.5[医药卫生—内科学]