HDL-C对2型糖尿病合并冠状动脉粥样硬化血管病变的影响  

Effect of high density lipoprotein-C on type 2 diabetes mellitus accompanying coronary atherosclerosis

作　　者：王晓娜[1] 刘宏斌[1] 张弢[1] 荆晶[1] 王国位[1] 

机构地区：[1]解放军总医院心内科,北京100853

出　　处：《军医进修学院学报》2011年第5期432-434,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的分析高密度脂蛋白胆固醇(HDL-C)对2型糖尿病合并冠状动脉粥样硬化患者血管病变的影响。方法选取227例2型糖尿病患者经冠状动脉造影(CAG)确诊为冠状动脉粥样硬化、且至少6个月后再次行CAG的患者,根据随访时高密度脂蛋白情况将患者分为A、B两组:A组为高密度脂蛋白上升或不变患者,B组为高密度脂蛋白下降患者。结果冠状动脉粥样硬化病变进展率A组20.6%B组36.5%(P<0.01),心绞痛复发率A组12.2%B组15.6%(P<0.05),再次血管重建发生率A组1.5%B组3.1%(P<0.01),以上指标A组明显低于B组。结论 HDL-C为2型糖尿病患者冠状动脉粥样病变的独立危险因素。Objective To analyze the effect of high density lipoprotein-C（HDL-C） on type 2 diabetes mellitus（DM） accompanying coronary atherosclerosis.Methods Two hundred and twenty-seven patients with type 2 DM diagnosed with coronary atherosclerosis by coronary arteriongraphy（CAG） and undergone CAG at least after 6 months were enrolled in this study.The patients were divided into group A and group B according to their HDL-C.HDL-C in patients of group A was increased or unchanged and decreased in patients of group B.Results The progression rate of coronary atherosclerosis was 20.6% in group A and 36.5% in group B（P0.01）.The incidence of angina pectoris was 12.2% in group A and 15.6% in group B（P0.05）.The target lesion revascularization was 1.5% in group A and 3.1% in group B（P0.01）.Conclusion HDL-C is an independent risk factor for coronary atherosclerosis in patients with type 2 DM.

关 键 词：冠状动脉粥样硬化 高密度脂蛋白胆固醇 2型糖尿病 冠脉造影 

分 类 号：R543.31[医药卫生—心血管疾病]