铜绿假单胞菌医院感染调查及耐药分析  

Surveillance on clinical distribution and antimicrobial resistance of Pseudomonas aeruginosa

作　　者：诸林俏[1] 黄晨[1] 周璇[1] 

机构地区：[1]温州医学院附属第二医院药剂科,浙江温州325027

出　　处：《中国微生态学杂志》2011年第4期353-355,共3页Chinese Journal of Microecology

摘　　要：目的探讨铜绿假单胞菌(PA)医院感染的临床分布及耐药性,为临床合理使用抗菌药物及控制医院感染提供依据。方法 PA的培养与鉴定严格按照《全国临床检验操作规程》进行。药敏试验采用纸片扩散法(K-B法)。结果收集的359株PA中,分离率居前3位的临床科室依次为ICU、呼吸内科和神经内科,分别占38.1%、17.5%和13.9%;临床标本中以呼吸道标本分离率最高,占62.7%;PA对头孢哌酮/舒巴坦的耐药率最低(9.7%),其次为阿米卡星(13.1%)和头孢他啶(17.8%),另12种抗菌药物的耐药率均较高。结论 PA耐药性已十分严重,临床应根据药敏结果合理使用抗菌药物并加强对细菌耐药性的全面监测。Objective To explore the clinical distribution and drug resistance of Pseudomonas aeruginosa（PA） in nosocomial infections,guide the use of antibiotics and provide evidence for nosocomial infection control.Method PA was cultured and identified according to the National Clinical Laboratory Operation Rules.Drug susceptibility testing was performed with K-B methods.Result Among the 359 strains of PA,the top three isolation rates were from intensive care unit（38.1%）,department of respiratory medicine（17.5%） and department of neurology（13.9%）.The isolation rate was the highest in the respiratory specimens,up to 62.7%.The lowest resistance rate of PA to the antimicrobial agents was to cefoperazone/sulbactam（9.7%）,followed by amikacin（13.1%） and ceftazidime（17.8%）.The drug resistance rates to other twelve antibiotics were high.Conclusion The drug resistance of PA is very serious.Clinicians should use antibiotics rationally in accordance with the results of drug susceptibility tests,and overall supervision of drug resistance should be strengthened.

关 键 词：铜绿假单胞菌 医院感染 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]