糖耐量正常的向心性肥胖患者8-异前列腺素水平及其与胰岛素抵抗的关系  

The level of 8-iso-prostaglandin F2α(8-iso-PGF2α)in the central obese patients with normal glucose tolerance (NGT) and its relationship with insulin resistance

作　　者：刘乐桐[1] 刘扬[1] 宫英丽[2] 何冰[1] 张咏言[1] 韩萍[1] 

机构地区：[1]中国医科大学附属盛京医院内分泌科,沈阳110004 [2]中国医科大学附属盛京医院体检中心,沈阳110004

出　　处：《中国糖尿病杂志》2011年第4期246-249,共4页Chinese Journal of Diabetes

基　　金：辽宁省教育厅科学技术基金项目(20060999)

摘　　要：目的观察向心性肥胖患者的8-异前列腺素(8-iSo-PGF2α)水平及其与胰岛素抵抗的关系。方法筛选糖耐量正常的向心性肥胖患者(包括胰岛素抵抗与无胰岛素抵抗者)及正常对照组。分别测定血清8-iso-PGF2α,丙二醛(MDA),游离脂肪酸(FFA)等。结果向心性肥胖组8-iso-PGF2α、MDA、胰岛素抵抗指数(HOMA-IR)、FFA均显著高于对照组(P<0.05)。8-iso-PGF2α差异最显著(P<0.01),且与FFA、BMI及甘油三酯(TG)呈显著正相关。胰岛素抵抗亚组的8-iso-PGF2α水平显著高于无胰岛素抵抗亚组。多元回归分析显示,8-iso-PGF2α与HOMA-IR相关性最强。结论糖耐量正常的向心性肥胖患者氧化应激增强,且氧化应激是胰岛素抵抗的重要危险因素,循环中8-iso--PGF2α水平能更好地反映其程度。Objective To investigate the level of 8 iso-prostaglandin F2α （8-iso-PGF2α） and its relationship with insulin resistance in central obese patients with NGT. Methods Two hundred and twenty-two subjects were enrolled and divided into two groups： central obese group （n=123） and normal control group（NC, n：99）. The central obese group was subdivided into insulin resistance（IR） group and non-IR group. Serum 8-iso-PGF2α, malondialdehyde （MDA）, free fatty acids （FFA）, IL-6, TNF-α, and lipid were measured. Results Compared with the control group, the levels of 8-iso-PGF2α（P〈0. 001）, body mass index（BMI）, waist circumference（WC）, triglyceride （TG）, cholesterol （TC）, high density lipoprotein（HDL）, FFA, MDA and insulin resistance index （HOMA-IR） significantly increased in obese group（all P〈0. 05）, and they increased even more in IR sub-group than those in non-IR sub-group. The level of 8-iso-PGF2α had independently positive correlation with HOMA-IR. Conclusion Oxidative stress increases in central obese patients with NGT, and it plays an important role in insulin resistance. The level of serum 8-iso-PGF2α is a better parameter indicating the extent of oxidative stress.

关 键 词：向心性肥胖 8-异前列腺素 氧化应激 胰岛素抵抗 

分 类 号：R589.2[医药卫生—内分泌]