2型糖尿病患者尿白蛋白排泄率与补体C5a的关系  

The relationship between complement C5a and UAER in type 2 diabetes mellitus

作　　者：周新人[1,2] 刘永铭[1] 杨琳[1] 王晓玉[1] 陈敏娟[1] 

机构地区：[1]兰州大学第一医院老年病科,兰州730000 [2]兰州军区总医院安宁分院感染科

出　　处：《中国糖尿病杂志》2011年第4期266-269,共4页Chinese Journal of Diabetes

摘　　要：目的探讨2型糖尿病患者血、尿补体活化片段C5a含量的变化与糖尿病肾病的关系。方法选2型糖尿病患者39例,健康体检者21名作为对照,检测血、尿C5a浓度以及血高敏C反应蛋白,测定尿白蛋白排泄率以及血糖控制情况,分析其关系。结果与对照组比较,2型糖尿病患者尿C5a浓度升高(11.4±21.1 vs 76.3±144.4,P<0.05),血C5a无明显变化,尿C5a与尿白蛋白排泄率正相关(r=0.378,P<0.05),糖尿病病程、尿C5a是尿白蛋白排泄率的独立预测因素。结论补体活化可能与糖尿病肾病的发生有关。Objective To investigate the relationship between complement CSa and diabetic nephropathy. Methods The concentration of plasma CSa and urine CSa was examined in 39 patients with type 2 diabetes mellitus, 21 healthy volunteers as controls. The relationship between complement CSa and UAER was analyzed. Resuts Urinary level of CSa was higher in the diabetic nephropathy group than in control （76. 3±144. 4 vs 11.4±21. 1, P=0. 046）, Urinary CSa was positively correlated with UAER. The diabetic course and urinary CSa were the independent predictors of urine albumin excretion rate （UAER） （r = 0. 378, P = 0. 023）. Conclusion The activation of complements might involve in the pathogenesis of diabetic nephropathy.

关 键 词：糖尿病 2型 尿白蛋白排泄率 C5A 

分 类 号：R587.1[医药卫生—内分泌]