雷公藤、防己水提物对大鼠胃黏膜环氧化酶的影响  

Effects of aqueous extract of Tripterygium Wilfordii and Stephaniae Tetrandrae radix on cyclooxygenase of rat gastric mucosa in rats

作　　者：邱建波 龙启才[2] 徐清 

机构地区：[1]广东省食品药品职业技术学校,510663 [2]中山大学药学院临床药理研究所

出　　处：《中国现代药物应用》2011年第5期14-15,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨雷公藤,防己水提取物对大鼠胃黏膜环氧化酶的影响。方法观察雷公藤、防己水提物对正常大鼠和乙醇诱导胃黏膜损伤大鼠的胃黏膜溃疡指数的变化;测定大鼠胃壁组织6-keto-PGF1α的含量。结果正常大鼠的胃黏膜溃疡指数和6-keto-PGF1α的含量在给药前后差异无统计学意义(P>0.05),而乙醇诱导大鼠的胃黏膜溃疡指数显著增加(P<0.05);6-keto-PGF1α的含量显著减少(P<0.05)。结论雷公藤、防己水提物对正常大鼠胃黏膜的环氧化酶无影响,但能抑制乙醇诱导大鼠胃黏膜中环氧化酶的活性。Objective To explore the effects of aqueous extract of Tripterygium Wilfordii and Stephaniae Tetrandrae radix on cyclooxygenase of rat gastric mucosa.Methods The ulcer index in rat gastric mucosa,include normal rat and injury rat caused by ethano1 were measured.The content of 6-keto-PGF1α in rat stomach tissue was determined.Results There was no significant difference in the ulcer index and the content of 6-keto-PGF1α between before and after drug administration in normal rat（P0.05）.But in injury rat caused by ethano1,the ulcer index increased significantly and the content of 6-keto-PGF1α decreased significantly（P0.05）.Conclusion The aqueous extract of Tripterygium Wilfordii and Stephaniae Tetrandrae radix have no effect on cyclooxygenase of normal rat gastric mucosa,but could inhibit the activity of cyclooxygenase in injury rat caused by ethanol.

关 键 词：雷公藤 防己 环氧化酶 

分 类 号：R285.5[医药卫生—中药学]