职业性苯所致白血病52例临床分析  

A clinical analysis of 52 leukemia cases due to occupational exposure to benzene

作　　者：郑倩玲[1] 梁伟辉[1] 李斌[1] 杨丽文[1] 郭卫军[1] 

机构地区：[1]广东省职业病防治院,广东广州510300

出　　处：《中国热带医学》2011年第2期237-238,共2页China Tropical Medicine

摘　　要：目的了解职业性苯所致白血病的临床特征。方法对52例职业性苯所致白血病的分型、分布、临床和实验室特征进行回顾性分析。结果 52例职业性苯所致白血病例平均发病年龄为(31.65±8.22)岁,平均接苯工龄(4.66±3.92)年,平均潜隐期为(5.09±4.30)年。71.15%为急性白血病,急性髓细胞白血病多见。临床表现为乏力38例,出血21例,发热13例.脾大21例,胸骨压痛18例,淋巴结肿大9例,肝大7例,髓外浸润较常见。实验室检查贫血47例,外周血出现幼稚细胞者50例,PLT偏低36例,PLT数量与出血之间呈负相关关系,骨髓增生活跃51例,骨髓粒、红、巨核三系均有不同程度的病态造血表现。结论苯所致白血病发病隐匿,临床类型多样。了解其的特点,有利于对疾病的诊治。Aim To investigate the clinical features of leukemia cases due to occupational exposure to benzene.Methods The clinical data of 52 leukemia cases with average age of 31.65±8.22 years due to occupational exposure to benzene were analyzed retrospectively.Results The average duration of benzene exposure in the cases were 4.66±3.92 years.The average latent period were 5.09±4.30 years.Among 52 patients,71.15% of the cases were acute leukemia（37/52）and acute myeloid leukemia was common.There were 38 fatigue cases,21 hemorrhagic cases,13 feverish cases,21 splenomegaly cases,18 sternum tenderness cases,9 enlarged lymph node cases,and 7 hepatomegaly cases.The extramedullary infiltration was common.There were also 47 anemia cases,juvenile cells were found in the peripheral blood of 50 cases,level of platelet was slight lower in 36 cases.The level of platelet was negatively correlated with hemorrhage.Activ hyperplasia of bone marrow was observed in 51 cases.Conclusion The onset of leukemia due to occupational exposure to benzene is invisible with versatile clinical features.

关 键 词：苯 白血病 临床分析 

分 类 号：R135.2[医药卫生—劳动卫生]