美罗培南治疗大肠埃希菌败血症的疗效分析  

Efficacy of meropenem for injection in treatment of septicemia due to Escherichia coli infection

作　　者：高学民[1] 赵丹丹[2] 

机构地区：[1]唐山市协和医院ICU,河北唐山063000 [2]华北煤炭医学院预防医学系/河北省煤矿卫生与安全实验室,河北唐山063000

出　　处：《中国热带医学》2011年第2期252-253,共2页China Tropical Medicine

摘　　要：目的研究美罗培南持续输注治疗大肠埃希菌败血症的临床效果。方法将63例感染大肠埃希菌的败血症患者随机分成两组,持续输注组35例,美罗培南1g输注6h,每6h 1次;间断输注组28例,美罗培南1g输注0.5h,每6h 1次。结果持续输注组SIRS评分下降时间、住ICU时间均较间断输注组为低,两组病死率分别为12.74%和35.71%(P<0.05)。结论美罗培南持续输注能缩短SIRS评分下降时间、住ICU时间,降低病死率。Aim To estimate the curative effect of continuous infusion of meropenem in treatment of septicemia patients due to Escherichia coli infection.Methods Sixty-three patients with septicemia due to Escherichia coli infection were randomly divided into continuous infusion group（CIG） consisted of 35 cases and treated with meropenem with dose of 1g over 360min for every 6 h,and intermittent infusion group（IIG） also treated with meropenem with dose of 1g over 30min for every 6h.Results The SIRS score reduction time and ICU observation duration of CIG patients were shorter compared to that of the IIG patients.The mortality of CIG patients was（12.74%） lower than that of the IIG ptients（35.71%）,showing significant difference between the two groups（P0.05）.Conclusion Meropenem administered by continuous infusion can reduce the time of SIRS decrease and the duration of ICU observation and reduce the mortality of patients due to septicemia.

关 键 词：美罗培南 持续输注 大肠埃希菌 败血症 随机对照试验 

分 类 号：R631.3[医药卫生—外科学]