不同冠心病血清soL-CXCL16,soL-ICAM1及hsCRP水平研究  

The level and clinical significance of sol-CXCL16,sol-ICAM1and hsCRP in patients with different coronary heart diseases

作　　者：陈阳[1] 

机构地区：[1]江苏省靖江市人民医院心血管科,江苏靖江214500

出　　处：《实用临床医药杂志》2011年第5期30-32,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨不同冠心病血清soL-CXCL16,soL-ICAM1及hsCRP水平及临床意义。方法选取冠心病患者61例,其中急性冠状动脉综合征(ACS)患者30例(ACS组),稳定型心绞痛(SAP)患者31例(SAP组),另选30例正常志愿者作为正常对照组。所有患者均检测soL-CXCL16,soL-ICAM1及hsCRP水平。并随访6个月的主要不良心血管病事件(MACE)。结果 ACS组比SAP组有较高的soL-CXCL16(P<0.05),soL-ICAM1(P<0.01)及hsCRP(P<0.05)水平,且2组均显著性高于正常对照组(P<0.05或P<0.01)。CXCL16与hsCRP、TG、CHO、LDL,存在相关性,而与其他指标均无相关性;但在ACS组、soL-CXCL16与soL-ICAM1有相关性,与其他指标无相关性。结论检测soL-CXCL16s、oL-ICAM1及hsCRP水平对冠心病有一定的临床诊断和预测意义。Objective To explore the serum level and their clinical significance of highsensitivity C - reactive protein（hs - CRP）, soluble CXC chemokine ligand 16 （sol - CXCL16） and soluble vascular cell adhesion molecule - 1 （ sol - VCAM - 1 ） in patients with different coronary heart diseases（CHD）. Methods Sixty one patients with CHD are randomized into acute coronary syndrome group（ACS group, 30 cases）and stable angina pectoris group（SAP group, 31 cases）, and 30 volunteers are selected as controls. Serum levels of sol - CXCL16, sol - ICAM1 and hsCRP are measured by enzyme - linked irnmunosorbent assay. Results The Serum levels of sol - CXCL16 （P 〈 0.05）, sol - ICAM1 （ P 〈 0.01 ） and hsCRP （ P 〈 0.05） in ACS group are higher than that in SAP group, which in both groups are higher than that in control（P〈0.05 or P〈0.01）. the level of sol - CXCL16 correlate with the levels of hsCRP, TG, CHO and LDL in all the selected , while it correlate with the level of sol - ICAM1 only in ACS group. Conclusion To detect the Serum levels of sol - CXCL16, sol - ICAM1 and hsCRP has some clinical diagnosis and prognostic significance to coronary heart disease.

关 键 词：冠状动脉疾病 动脉粥样硬化 炎症 CXC趋化因子配体16 

分 类 号：R541.4[医药卫生—心血管疾病]