乳腺柱状细胞病变的形态及免疫表型特征  

Morphologic and immunohistochemical characteristics of columnar cell lesions of the breast

作　　者：任丹[1] 杜金荣[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院病理科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2010年第6期563-566,共4页Journal of Harbin Medical University

摘　　要：目的探讨乳腺柱状细胞病变的形态及免疫表型特征。方法对60例乳腺组织行CK5/6、CK8/18及p73检测。结果中-重度不典型柱状细胞增生中CK5/6的上皮表层和p73的阳性表达率分别为22.2%和88.9%,明显不同于柱状细胞变、柱状细胞增生和轻度不典型柱状细胞变/增生,差异具有显著性(P<0.05)。结论乳腺柱状细胞变、柱状细胞增生、轻度不典型柱状细胞变/增生,其与导管原位癌的相关性并不是很大,但中-重度不典型柱状细胞增生可能为癌前病变。Objective To investigate morphologic and immunohistochemical characteristics of columnar cell lesions of the breast.Methods Specimens from breast tissue（60 cases） were analyzed by immunohistochemical detection for CK5/6、CK8/18 and P73 expressions.Results The positive rates of cavity CK5/6 and P73 were 22.2% and 88.9% respectively in moderate-severe atypical columnar cell hyperplasia.The positive rates in moderate-severe atypical columnar cell hyperplasia were significantly different from other groups（P0.05）.Conclusion The relationships between columnar cell change,columnar cell hyperplasia,mild atypical columnar cell change/hyperplasia and ductal carcinoma in situ are not closer,but moderate-severe atypical columnar cell hyperplasia may be precarcinomatous lesions.

关 键 词：乳腺 柱状细胞病变 CK5/6 免疫组织化学 

分 类 号：R446.8[医药卫生—诊断学]