β-TCP/α-CSH复合植骨材料固化性能与力学强度  

Study on the setting property and compressive strength of β-TCP/α-CSH combined bone graft

作　　者：毛克亚[1] 李江涛[2] 杨云[2] 侯喜军[1] 梁茂华[1] 王继芳[1] 杜明奎[1] 王征[1] 温宁[1] 王岩[1] 

机构地区：[1]解放军总医院骨科,北京100853 [2]中国科学院理化技术研究所,北京100190

出　　处：《医用生物力学》2010年第6期456-459,478,共5页Journal of Medical Biomechanics

基　　金：国家自然科学基金资助项目(50772132);全军"十一五"科研基金(2005jd0003);国家863计划资助项目(2009AA02Z405)

摘　　要：目的检测β-磷酸三钙(β-TCP)/α-半水硫酸钙(α-CSH)复合人工骨的固化性能与力学强度。方法将β-TCP/α-CSH复合人工骨与蒸馏水按1g:0.1 mL、1g:0.2 mL、1g:0.3 mL、1g:0.4 mL、1g:0.5 mL的比例混合,测试其初凝时间、终凝时间、压缩强度,并进行X线衍射和扫描电镜观察。结果复合人工骨的固化时间均随着固化液比例的增加,初凝时间和终凝时间逐渐延长,固液比为1g:0.2 mL时初凝时间为(4.6±1.3)min,终凝时间为(13.1±2.9)min。复合人工骨的平均抗压强度固化1 d时达到7.86 MPa,较近单相β-TCP组升高约1倍,XRD检测固化后没有其他物质产生,只是α-CSH在固化过程中转化为二水硫酸钙(CSD),扫描电镜可见固化后粗大CSD颗粒形成短柱状结构覆盖在多孔状β-TCP表面。结论通过调整β-TCP/α-CSH的固液比可以调整其固化时间和压缩强度。Objective To investigate the setting property and compressive strength of β-TCP（β-tricalcium phos-phate） /α-CSH（α-calcium sulphate hemihydrate） combined bone graft.Method β-TCP/α-CSH combined bone graft and distilled water were mixed with different ratio： 1 g ∶ 0.1 mL、1 g ∶ 0.2 mL、1 g ∶ 0.3 mL、1 g ∶ 0.4 mL、1 g∶ 0.5 mL,respectively.The initial setting time（Ti）,final setting time（TF）,compressive strength were recorded,and the X-ray diffraction（XRD） and the scanning electron microscope（SEM） were examined.Re-sults The initial and final setting time of combined bone graft increased along with the increase of solid/liquid ra-tio.The Ti and TF were（4.6 ±1.3） min and（13.1 ±2.9） min respectively when the solid/liquid ratio was 1 g ∶ 0.2 mL.The average compressive strength was 7.86 MPa in one day after setting,which was about two times higher than that of β-TCP alone.The XRD results showed that no other materials were produced except that α-CSH was transformed to CSD in the setting process.The SEM results indicated that thick CSD granules were ad-hered to the porous surfaces of β-TCP granules after setting.Conclusions The setting time and compressive strength of β-TCP/α-CSH combined bone graft could be adjusted by the different solid/liquid ratio.

关 键 词：Β-磷酸三钙 α-半水硫酸钙 复合植骨材料 固化 力学强度 

分 类 号：R3[医药卫生—基础医学]