化学突触传递的数值模拟  

The Numerical Simulation of Chemical Synaptic Transmission

作　　者：刘利华[1] 刘深泉[1] 

机构地区：[1]华南理工大学理学院,广州510640

出　　处：《北京生物医学工程》2011年第2期117-119,126,共4页Beijing Biomedical Engineering

基　　金：国家自然科学基金(10872069)资助

摘　　要：为了进一步认识突触功能,构造了两个简单的突触连接模型,并对化学突触传递进行模拟,数值研究化学突触的传递功能。研究结果表明,神经信号通过化学突触进行传递时,存在明显的突触延搁现象;突触后膜上化学门控离子通道的开放比例与突触前膜电位呈正相关;化学突触传递存在阈电位。上述结果与神经生物学的相关理论基本吻合。本研究以数值模拟方法进一步认识和理解了神经元之间的信号传递过程,也为后续的神经网络的模拟仿真研究奠定基础。In order to further understand the principles of synapsis,we constructed two simple models and numerically simulated the connection of chemical synapsis. The simulating results indicated that the synaptic delay happened evidently when neural signals were passed through the chemical synapse. And the opening proportion of chemical-gated ion channels on postsynaptic membrane was positively related to the potential of presynaptic membrane. There existed threshold potential when neural signals were passed through the chemical synapse. These results are consistent with the related theories of neurobiology. This study provides a thorough understanding to the signals transmission between neurons,and lays a foundation to the simulation of neural network further.

关 键 词：锥体神经元 中间神经元 化学突触 传递功能 离子通道 

分 类 号：R318.04[医药卫生—生物医学工程]