杠柳毒苷在大鼠体内的组织分布  

In vivo tissue distribution of periplocin in rats

作　　者：高淑红[1,2] 谢跃生[3] 肖学凤[2] 许妍妍[2] 张智禹[4] 刘昌孝[2,5] 

机构地区：[1]山西生物应用职业技术学院,山西太原030031 [2]天津中医药大学中药学院,天津300193 [3]华北煤炭医学院,河北唐山063000 [4]天津大学化工学院,天津300072 [5]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193

出　　处：《现代药物与临床》2011年第2期116-118,共3页Drugs & Clinic

基　　金：国家自然科学基金资助项目(30973932);高等学校博士学科点专项科研基金资助项目(20070063001)

摘　　要：目的考察杠柳毒苷在大鼠体内的组织分布。方法采用高效液相色谱法测定大鼠静脉注射杠柳毒苷后,组织样品中杠柳毒苷的质量浓度。结果大鼠iv杠柳毒苷0.74mg/kg,2、10、20 min后肝中杠柳毒苷的质量浓度分别为(2.447±0.687)、(0.631±0.272)、(0.292±0.228)μg/g,在肝中最高,其次是肾、心、肺、脾和脑。结论杠柳毒苷静脉注射后,在大鼠体内分布迅速,主要分布于肝、肾和心中。Objective To investigate the in vivo tissue distribution ofperiplocin in rats. Methods An established HPLC-UV method was utilized to determine tissue concentrations Of periplocin after iv injection. Results After a single iv dose 0.74 mg/kg to rats, periplocin concentrations in 2, 10, and 20 rain was （2.447±0.687）, （0.631±0.272）, and （0.292±0.228） μg/g in liver, respectively. So the periplocin concentration was maximum in liver followed by kidney, heart, lung, spleen, and brain. Conclusion Periplocin is distributed in rat tissues rapidly following iv injection, and could be mainly distributed in liver, kidney, and heart.

关 键 词：杠柳毒苷 组织分布 肝 肾 心 高效液相色谱 

分 类 号：R285.5[医药卫生—中药学] R293[医药卫生—中医学]