地氟醚和异氟醚麻醉对围手术期心肌缺血发生的比较研究  

The incidence of perioperative myocardial ischemia:a comparison of desflurane and isoflurane anesthesia

作　　者：陈晓光[1] 王俊科[1] 傅文[1] 张晓光[1] 马虹[1] 

机构地区：[1]中国医科大学第一临床学院麻醉科,沈阳市110001

出　　处：《中华麻醉学杂志》1999年第7期392-394,共3页Chinese Journal of Anesthesiology

摘　　要：目的　比较地氟醚和异氟醚麻醉围手术期心肌缺血的发生率 ,探讨地氟醚在冠心病病人应用的安全性。方法　 60例择期腹部手术病人 ( ASA ～ 级 ) ,分为地氟醚组和异氟醚组。用动态心电图监测围手术期 ST段变化情况 ,求得各组病人围手术期缺血发生率及严重程度。结果　两组病人围手术期心肌缺血发生率为 4 4%和 4 6% ;术后缺血发生率约为术前的 2倍 ,术中与术前相比无差异 ( P>0 .0 5 )。结论　地氟醚与异氟醚相比不增加冠心病及其高危因素病人围手术期心肌缺血的发生率。Objective To compare the influences of desflurane and isoflunane on the incidence of perioperative myocardial ischemia in high risk patient with coronary artery disease.Methods Sixty patients with coronary artery disease were scheduled for elective abdominal operation and randomly classified randomly to receive desflurane or isoflurane.Perioperative ischemia was assessed using Holter electrocardiography and the incidence and characteristics of ECG ischemia were recorded.Results The incidence of perioperative ischemia was 44% in desflurane group and 46% in isoflurane group without significant difference between them(P>0.05);during postoperative period ECG ischemia changes were observed in 33.3% of patients in desflurane group and 36.7% in isoflurane group with significant difference compared with preoperation or intraoperation(P<0.05).Conclusion The influences of desflurane and isoflurane anesthesia on the incidence of perioperative myocardial ischemia are similar in patients with coronary artery disease.

关 键 词：地氟醚 异氟烷 心肌缺血 麻醉 围手术期 

分 类 号：R971.2[医药卫生—药品]