树突状细胞对小鼠实验性自身免疫性甲状腺炎的作用  

The effects of dendritic cell in murine experimental autoimmune thyroiditis

作　　者：王胜军[1] 许化溪[1] 刘恭植[1] 柳龙图[1] 江淑芳[2] 

机构地区：[1]镇江医学院免疫学研究室 [2]南京81医院

出　　处：《中国免疫学杂志》1999年第7期294-295,共2页Chinese Journal of Immunology

基　　金：国家自然科学基金;江苏省教委自然科学基金

摘　　要：目的：研究树突状细胞（ＤＣ）对小鼠实验性自身免疫性甲状腺炎（ＥＡＴ）的作用。方法：体外检测ＴｇＡｂ、Ｔｇ刺激的淋巴细胞增殖能力、ＩＬ１、ＴＮＦ水平，并对甲状腺进行病理学检查。结果：ＤＣ注射组早期ＴｇＡｂ、Ｔｇ刺激的淋巴细胞增殖能力以及ＩＬ１的水平均显著高于ＤＣ不注射组，但ＴＮＦ水平在两者间无明显差异；经ＤＣ单抗处理组的上述指标均低于ＤＣ注射组；病理学检查表明ＤＣ注射组甲状腺局部病变较其它各组严重。结论：ＤＣ对小鼠ＥＡＴ具有明显促进作用。Objective: To investigate the function of dendritic cell in murine experimental autoimmune thyroiditis. Methods: Levels of thyroglobulin antibody , interleukin1 and tumor necrosis factor, proliferation of lymphocyte to thyroglobulin stimulation were detected in vitro. The histological pictures of thyroid were assessed. Results: The levels of TgAb ( early phase) and IL1, proliferation of lymphocyte to thyroglobulin stimulation in the DC group were higher than that in the nonDC group(P<0.01),but the levels of TNF weren't significantly different between two groups(P>0.05).These data in monoclonal antibody(33D1) group were markedly decreased.In addition,the pathologic pictures showed that the damage of thyroid was heavy in DC group. Conclusion: These suggested that the DC could improve the progress of murine experimental autoimmune thyroiditis.

关 键 词：树突状细胞 自身免疫 甲状腺炎 小鼠 

分 类 号：R581.403[医药卫生—内分泌]