早产合并临床绒毛膜羊膜炎时母血和脐血中细胞因子的检测  

Maternal and umbilcal cord serum cytokines level in preterm labor with clinical chorioamnitis

作　　者：刘素英[1,2,3] 夏振开[1,2,3] 高美华[1,2,3] 王海燕[1,2,3] 胡涛[1,2,3] 

机构地区：[1]山东滨州医学院附属医院妇产科 [2]滨州医学院计划生育研究室 [3]滨州医学院免疫教研室

出　　处：《中国免疫学杂志》1999年第7期315-316,共2页Chinese Journal of Immunology

摘　　要：目的：探讨早产合并临床绒毛膜羊膜炎时母血和脐血中细胞因子的变化。方法：应用ＥＬＩＳＡ法测定３１例早产合并临床绒毛膜羊膜炎孕妇（Ａ组）外周血和脐血中肿瘤坏死因子（ＴＮＦα）、白细胞介素６（ＩＬ６）和白细胞介素８（ＩＬ８）含量，并以３５例早产孕妇作对照（Ｂ组）。结果：Ａ组母血中ＴＮＦα、ＩＬ８均显著高于Ｂ组（Ｐ＜００５），脐血中ＩＬ６显著高于Ｂ组（Ｐ＜００２），母血中ＩＬ６，脐血中ＴＮＦα和ＩＬ８在Ａ、Ｂ两组中无显著性差异。结论：早产合并临床绒毛膜羊膜炎时细胞免疫功能增强。Objective: To investigate the change of cytokines of maternal and umbilical cord serum in preterm labor with clinical chorioamnitis. Methods: 31 women with chorioamnitis between 29 and 36 weeks gestation( group A) were studied and 35 women without chorioamnitis were delivered between 28 and 36 weeks gestation (group B) as control, TNFIL6 and IL8 were measured by Enzymelinked immunosorbent assay. Results: TNF and IL8 concentrations in maternal sera in group A were significantly higher than those in group B(P<0.05) and IL6 concentrations in umbililcal cord sera in group A were significantly higher than that in group B(P<0.02), no significant difference in maternal IL6, umbilical cord TNF and IL8 concentrations were noted in both groups. Conclusion: For patients with preterm labor and clinical chorioamnitis the cellmediated immunity is activated.

关 键 词：早产 绒毛膜羊膜炎 细胞因子 免疫 

分 类 号：R714.210.3[医药卫生—妇产科学]