中国湖北汉族人群对同种异型抗原免疫应答与HLA遗传多态性的相关性  

Association between the immune response to alloantigens and the genetic polymorphism of HLA in a Hubei population of the Han nationality

作　　者：涂正坤[1,2] 吴雄文[1,2] 刘敏 姜晓丹[1,2] 杨志章 吴锋[1,2] 龚非力 赵修竹[1,2] 

机构地区：[1]广州市妇婴医院医学遗传研究所 [2]同济医科大学免疫学教研室

出　　处：《中华微生物学和免疫学杂志》1999年第4期298-301,共4页Chinese Journal of Microbiology and Immunology

摘　　要：目的研究个体之间混合淋巴细胞反应强度的差异，探讨中国汉族人群对同种异型抗原的应答水平与ＨＬＡ的相关性。方法在１７个家系中进行父／子和母／子间单向混合淋巴细胞培养。结果和结论不同组合的混合淋巴细胞反应强度，即父→子与子→父相比；母→子与子→母相比；父／子间与母／子间相比，差异均无显著性。个体对同种异型抗原的免疫应答的强度与ＨＬＡ－Ⅰ类分子的型别相关，ＨＬＡ－Ａ１０表型阳性个体的刺激指数ＳＩ（０．９５±０．２４）明显低于阴性个体（１．４１±０．６９），差异具有极显著性意义。Objective To study the difference in the magnitude of mixed lymphocyte culture reaction (MLC) among different individuals and discuss the association between the immune response to alloantigens and the genetic polymorphism of HLA. Methods We carried out the one way MLC between parents and children in seventeen Hubei families of the Han nationality. Results and Conclusion Our results showed that, the difference in the magnitude of MLC was not significant among various associations including father vs son/son vs father, mother vs son/son vs mother and father vs son/mother vs son. The intensity of the immune response to alloantigens were associated with the HLA class I phenotype, instead of the HLA DRB1 alleles. The stimulation index (SI) of individuals bearing HLA A10 antigen (0.95±0.24) was significantly lower ( P <0.01) than that of HLA A10 negative ones (1.41 ±0.69).

关 键 词：HLA 同种异型抗原 淋巴细胞 免疫应答 湖北 汉族 

分 类 号：R392.11[医药卫生—免疫学]