吡格列酮对高脂血症大鼠SOD活性和MDA水平的影响  

The influence of total pioglitazone on the activity of serum superoxide dismutase and level of malonaldehyde in hyperlipemia rats

作　　者：蔡辉[1] 赵凌杰[1] 董晓蕾[1] 赵智明[1] 郁郁[1] 

机构地区：[1]南京军区南京总医院中西医结合科,江苏南京210002

出　　处：《东南国防医药》2011年第2期97-99,共3页Military Medical Journal of Southeast China

基　　金：中国博士后基金资助课题(20090461491)

摘　　要：目的观察吡格列酮对高脂血症大鼠血清超氧化物歧化酶(SOD)活性和丙二醛(MDA)水平的影响。方法复制高脂血症大鼠模型,造模成功后随机分为对照组(8只)和治疗组[9只,吡格列酮10 mg/(kg.d)],干预4周后测量各组大鼠的SOD活性和MDA水平。结果高脂饮食喂养12周后,高脂饮食组TG、TC、LDL水平分别为1.74、3.50、0.45 mmol/L,均明显高于正常组(分别为0.93、1.83、0.20 mmol/L),且P值均小于0.01,提示造模成功。干预4周后治疗组的SOD活性为640.72U/m l,较对照组247.40 U/m l明显升高(P<0.01)。治疗组的MDA水平为2.46 nmol/m l,较对照组4.11nmol/m l明显降低(P<0.01)。结论吡格列酮能够提升高脂血症大鼠的SOD活性,降低MDA水平。Objective To investigate the influence of pioglitazone on the activity of serum superoxide dismutase and level of malonaldehyde in hyperlipemia rats.Methods 26 male SD rats were randomly divided into the high-fat diet group（17） and full diet group（9）.High-fat diet group were fed for 12 weeks,then 17 male SD rats were randomly divided into two groups： the hyperlipemia group（8）,group of high hyperlipemia with pioglitazone（9）.The group of pioglitazone was lavaged with pioglitazone 10 mg/kg every day.After 4 weeks of intervention with pioglitazone,the activity of serum superoxide dismutase and level of malonaldehyde were measured.Results The levels of TG,TC and LDL in hyperlipemic group（1.74 mmol/L,3.50 mmol/L,0.45 mmol/L） were significantly increased compared with full diet group（0.93 mmol/L,1.83 mmol/L,0.20 mmol/L） after 12 weeks（P〈0.01）,which indicates that the model of hyperlipemia has been established.Compared with the controls（247.40 U/ml）,the activity of serum superoxide dismutase（640.72 U/ml）was elevated after the intervention with pioglitazone,while the level of malonaldehyde（2.46 nmol/ml） was decreased.Conclusion Pioglitazone plays an important role in protecting the function of endothelial cells by elevating the activity of serum superoxide dismutase and decreasing the level of malonaldehyde in hyperlipemia rats.

关 键 词：高脂血症 吡格列酮 超氧化物歧化酶 丙二醛 

分 类 号：R589.21[医药卫生—内分泌]