亚洲人群白细胞介素8-251基因多态性与胃癌易感性的Meta分析  

Interleukin-8-251 genetic polymorphisms and susceptibility of gastric cancer among Asians:A Meta-analysis

作　　者：李光辉[1] 刘流[2] 刘浩[1] 刘熹[1] 刘进[1] 马立泰[1] 

机构地区：[1]四川大学华西医院骨科,四川省成都市610041 [2]四川大学华西医院胃肠外科,四川省成都市610041

出　　处：《中国组织工程研究与临床康复》2010年第50期9471-9474,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:炎性因素在胃癌发生过程中起重要作用,白细胞介素8在许多肿瘤组织均有明显表达。目的:定量分析白细胞介素8-251基因位点多态性与亚洲人群胃癌易感性的关系。方法:检索Medline,Embase和CNKI数据库,共纳入9篇以亚种人群为研究对象的病例对照研究。采用Stata10.0统计软件对其结果进行定量分析,同时依据研究对象来源进行分层分析,综合评价白细胞介素8-251基因位点多态性与胃癌发生的关系。结果与结论:白细胞介素8-251TT基因位点及A基因位点在(AA+AT)在非中国亚洲人群的合并OR值及95%CI分别为[0.83,0.71～0.96]和[1.13,1.00～1.28],具有显著性差异。白细胞介素8-251AA基因位点及T基因位点(AT+TT)在亚洲人群的合并OR值及95%CI分别为[1.15,0.91～1.45]和[0.99,0.90～1.07],均无显著性差异。白细胞介素8-251TT基因位点和A基因位点在(AA+AT)在中国人群的合并OR值及95%CI分别为[1.02,0.85～1.22]和[1.00,0.87～1.15],均无显著性差异。因此,白细胞介素8-251基因多态性与非中国亚洲人群胃癌易感性有关。携带白细胞介素8-251A基因位点的非中国亚洲人群可能是胃癌高危人群,而携带TT等位基因的非中国亚洲人群可能是胃癌的低危人群。BACKGROUND：Inflammatory factors play an important role in gastric cancer.Interleukin 8（IL-8） can be found in many tumor tissues.OBJECTIVE：To quantitative analyze the relationship between IL-8-251 genetic polymorphisms and susceptibility of gastric cancer.METHODS：Medline,Embase and CNKI databases were searched and 9 case-control studies among Asians were included.Stata 10.0 software was used to quantitatively analyze the relationship between IL-8 genetic polymorphisms and risk of gastric cancer.At the same time,stratified analysis was made according to participants from different areas of Asian countries.RESULTS AND CONCLUSION：The combined OR and 95% CI for IL-8-251 TT genotype and A carrier genotype（AA＋AT） among non-Chinese Asians were [0.83,0.71-0.96] and [1.13,1.00-1.28],they reached statistical significance.The combined OR and 95% CI for IL-8-251 AA genotype and T carrier genotype（AA＋AT） among Asians were [1.15,0.91-1.45] and [0.99,0.90-1.07],they did not reach statistical significance.The combined OR and 95% CI for IL-8-251 TT genotype and A carrier genotype（AA＋AT） among Chinese were [1.02,0.85-1.22] and [1.00,0.87-1.15],they did not reach statistical significance.IL-8-251 genetic polymorphisms might be correlated with susceptibility of gastric cancer among non-Chinese Asians.Non-Chinese Asians with A carrier genotype（AA＋AT） might be at high risk of gastric cancer development.In contrast,non-Chinese Asians with TT genotype might be at low risk of gastric cancer development.

关 键 词：胃癌 白细胞介素8 基因多态性 易感性 META分析 

分 类 号：R318[医药卫生—生物医学工程]