生物材料在膝交叉韧带运动损伤修复中的应用  

Application of biomaterials in repair of sports injury to knee cruciate ligament

作　　者：葛廷云[1] 

机构地区：[1]河北体育学院运动人体科学系,河北省石家庄市050041

出　　处：《中国组织工程研究与临床康复》2010年第51期9655-9658,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:通过对膝关节的结构和力学特征进行分析,阐明交叉韧带的损伤机制,并综述交叉韧带修复材料的种类与特点,为预防膝交叉韧带损伤及损伤后修复提供参考。方法:由第一作者应用计算机检索2000-01/2010-09中国知网数据库(http://www.cnki.net/index.htm)及Pubmed数据库(http://www.ncbi.nlm.nih.gov/PubMed)有关生物材料修复膝交叉韧带损伤的基础及临床应用研究,中文关键词为"韧带,损伤,重建",英文关键词为"ligament,injury,reconstruct"。排除重复及陈旧文献,对资料进行初审,并查看每篇文献后的引文。结果:依据纳入标准共保留文献28篇。膝关节受力的突发性和复杂性是造成其损伤的重要原因。交叉韧带损伤是膝关节损伤中的重要类型,由于交叉韧带自身愈合能力差,多采用关节镜下移植物重建。在交叉韧带重建中,修复材料主要有自体或同种异体移植物和人工材料两大类。目前对膝交叉韧带重建的临床研究多从重建材料、重建效果及重建技术等方面进行。对膝交叉韧带的实验研究多从促进腱-骨愈合、微血管生成、胶原重塑等角度出发,探讨组织工程韧带种子细胞及生长因子的作用。结论:膝交叉韧带损伤是膝关节损伤中的常见现象,在交叉韧带重建中,无论是自体移植物、同种异体移植物或人工韧带都存在一定的弊端,因此,随着组织工程技术的发展,寻找一种生物性、机械性与正常韧带相容、生物力学与正常韧带匹配的新型人工韧带是人们未来研究的方向。OBJECTIVE：By analyzing the structure and mechanical characteristics of knee joint,this study aims to clarify the mechanism underlying cruciate ligament injury,and to review the types and characteristics of cruciate ligament repair materials,thus providing evidence for the prevention of knee ligament injury and repair after injury.METHODS：A computer-based online search of CNKI Database （http：//www.cnki.net/index.htm） and Pubmed database （http：//www.ncbi.nlm.nih.gov/PubMed） from January 2000 to September 2010 was performed by the first author for basic and clinical application about biomaterials in repair of knee cruciate ligament injury,using the keywords of ＂ligament,damage,reconstruction＂ in Chinese and in English.Duplicated and old studies were excluded,and the data were preliminarily checked,and citations after each article were also searched.RESULTS：Accordance with inclusion criteria,28 article were selected.The sudden knee force and complexity are important reasons for knee injury.Cruciate ligament injury is an important type of knee injury,due to poor healing capacity of cruciate ligament itself,the main treatment is arthroscopic allograft reconstruction.In cruciate ligament reconstruction,repair materials include autologous graft or allograft and artificial materials.Present clinical study on knee cruciate ligament reconstruction is developed in reconstruction materials,reconstruction effects and reconstruction techniques.Experimental studies on knee cruciate ligament focus on the promotion of tendon-bone healing,angiogenesis,collagen remodeling,aims to investigate the role of seed cells and growth factors for tissue engineering ligament.CONCLUSION：Knee cruciate ligament injury is a common phenomenon in knee injury,in cruciate ligament reconstruction,both autograft,allograft,or artificial ligaments have certain disadvantages,with the development of tissue engineering,future research should investigate a new artificial ligament,which is biological,mechanical compatible with normal li

关 键 词：人工韧带 修复材料 交叉韧带 损伤 生物相容性 

分 类 号：R318[医药卫生—生物医学工程]