药物代谢酶在肿瘤耐药性中的研究进展  

Roles of drug metabolism enzymes in drug resistance of tumor

作　　者：周颖[1] 周芳[1] 吴晓兰[1] 王广基[1] 

机构地区：[1]中国药科大学药物代谢重点实验室

出　　处：《中国临床药理学与治疗学》2010年第12期1418-1427,共10页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金："十一五"重大新药创制专项资助(2009ZX09304-001;2009ZX09103);国家自然科学基金资助(30801411;30973583)

摘　　要：肿瘤化学治疗法是目前肿瘤治疗最常用且最有效的方法之一,而在肿瘤化疗过程中出现的耐药现象是导致化疗失败的主要原因。肿瘤耐药的产生机制复杂多样,其中药物代谢酶在肿瘤耐药的发生发展中也极为重要。目前研究显示,有多种药物代谢酶如Ⅰ相代谢中的细胞色素P450酶、环氧合酶等,Ⅱ相代谢中的谷胱甘肽转移酶、葡萄糖醛酸转移酶、葡萄糖神经酰胺合成酶、还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)依赖型醌还原酶等以及一类被称作Ⅲ相反应酶类的药物外排泵,如P-糖蛋白等与肿瘤多药耐药的发生密切相关。本文就近年来有关的药物代谢酶与肿瘤耐药的相关性研究作一综述。Tumor chemotherapy is one of the most commonly used and effective treatment in antitumor therapy,but drug resistance usually leads to tumor chemotherapy failure.Drug resistance of tumor is often caused by varied mechanisms,of which the drug metabolism enzymes play very important role.In recent years,researchers found that there were many kinds of drug metabolism enzymes related to drug resistance of tumor.Such as Phase I enzymes（cytochrome P450 enzymes,COX-2）,PhaseⅡ enzymes（GST,UGT,GCS,NQO1）,and Phase Ⅲ enzymes drug transporter protein.In this article,we reviewed the correlation between drug metabolism enzymes and drug resistance of tumor,in order to provide a new way for anti-tumor therapy.

关 键 词：药物代谢酶 肿瘤耐药 肿瘤 

分 类 号：R969[医药卫生—药理学]