D-二聚体检测在肾脏病诊断中的应用价值  

The Clinical Significance of Determination of D-dimer in Patients with Kidney Disease

作　　者：李香玲[1] 王炎强[2] 赵学兰[2] 李凯[2] 张琳琳[2] 肖青[2] 

机构地区：[1]潍坊医学院内科学教研室,山东潍坊261053 [2]潍坊医学院附属医院

出　　处：《潍坊医学院学报》2010年第6期431-433,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨血D-二聚体（D-D）在肾脏病中的变化及临床意义。方法应用ELISA法测定肾病综合征、糖尿病肾病、高血压肾病、狼疮肾炎、急性肾小球肾炎、慢性肾小球肾炎、慢性肾功能衰竭患者及正常健康对照者血D-二聚体、24h尿蛋白定量、血白蛋白水平。结果各组血D-二聚体水平均显著高于正常对照组（P〈0．05）。经治疗后，血D-二聚体水平较治疗前明显下降（P〈0．05）。结论血D-二聚体水平能直接反映’净脏病高凝与纤溶状态，对临床治疗及疗效、预后判断有重要意义。Objective To explore the clinical significance of the change of the D-dimer（D-D） level in kidhey disease. Methods The level of plasma D-dimer,24h urinaly protein and serum albumin were detected using ELISA method in patients with nephrotie syndrome, diabetic nephropathy, hypertensive nephropathy, Lupus nephritis, acute glomeruhmephritis,chronie glomerulonephritis, chlxmie renal failure patients anti heahhy control. Results The level of plasma D dimer in all groups was significantly higher than that of the normal control group （ P 〈 0.05 ）. Alter treatment, plasma D-direct level decreased significantly than before treatment（ P 〈 0.05 ）. Conclusion Plasma D-dimer level can directly reflect hypereoagulable and hyperfibrinolysis status in the kidney disease, which is important for the treatment, therapeutic effect and the prognosis.

关 键 词：D-二聚体 肾病综合征 糖尿病肾病 高血压肾病 狼疮肾炎 

分 类 号：R692[医药卫生—泌尿科学]