2型糖尿病患者血浆α2-HS糖蛋白水平与下肢血管硬化的关系  

Relationship of Plasma α2-Heremans-Schmid Glycoprotein Level with Lower Extremity Atherosclerosis in Patients with Type 2 Diabetes

作　　者：谭洪[1] 王玲[1] 卜锐[2] 王丹[2] 杨秋萍[1] 

机构地区：[1]昆明医学院附属第一医院糖尿病科,云南省昆明市650032 [2]昆明医学院附属第一医院超声科,云南省昆明市650032

出　　处：《中国动脉硬化杂志》2010年第12期969-971,共3页Chinese Journal of Arteriosclerosis

基　　金：云南省自然科学基金(2009CD166)资助

摘　　要：目的探讨2型糖尿病患者血浆α2-HS糖蛋白水平与下肢血管硬化的关系及其影响因素。方法 2型糖尿病患者245例,正常对照者88例,ELISA检测血浆α2-HS糖蛋白水平,彩色超声多普勒检测下肢血管硬化程度,同时测定总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、肌酐、尿素氮及空腹血糖水平。比较两组间的差异,逐步回归分析探讨影响α2-HS糖蛋白水平的因素。结果糖尿病组α2-HS糖蛋白水平、收缩压、舒张压、尿素氮、肌酐、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白及低密度脂蛋白水平以及体质指数、血管硬化评分均高于正常对照组,协方差分析校正这些因素对α2-HS糖蛋白的影响后,两组间α2-HS糖蛋白水平仍有统计学意义(P<0.01)。逐步回归分析显示,α2-HS糖蛋白水平与年龄负相关(P=0.011),与血管硬化正相关(P=0.001)。结论糖尿病组血浆α2-HS糖蛋白水平升高,其原因与胰岛素抵抗有关。血浆α2-HS糖蛋白水平与血管硬化评分正相关,与年龄负相关。Aim To investigate the correlation and factors of plasma α2-heremans-schmid glycoprotein（AHSG） level and lower extremity atherosclerosis（LEA） in patients with type 2 diabetes. Methods Two hundred and forty five patients with type 2 diabetes and eighty-eight normal controls were enrolled.In these subjects,the plasma AHSG level were detected by enzyme linked immunosorbent assay（ELISA）,and the degrement atherosclerosis of lower extremity was examined by Color Doppler Ultrasound,and TC,TG,HDL,LDL,Cr,BUN and fasting blood glucose（FBG） were measured.The differences were compared between the two groups.The effect factors of AHSG level by multiple stepwise regression analysis were defined. Results The plasma levels of AHSG,SBP,DBP,BMI,BUN,Cr,FPG,TC,TG,HDL and LDL and scroces of LEA in the diabetic group were higher than those in the normal control group（P0.01）.After multiple stepwise regression analysis,there was a negative correlation between plasma AHSG level and age（P=0.011）,but there was a positive correlation between LEA and age（P=0.001）. Conclusions The plasma AHSG level in the diabetic group was higher than that in the normal control,maybe mainly due to insulin resistance.The plasma AHSG level had a positive correlation with LEA,but a negative correlation with age.

关 键 词：α2-HS糖蛋白 2型糖尿病 下肢血管硬化 

分 类 号：R5[医药卫生—内科学]