湖南汉族人纤维蛋白原β148C/T基因多态性与脑梗死和血浆纤维蛋白原水平的相关性  

Association of Fibrinogen β148C/T Gene Polymorphism with Cerebral Infarction and Plasma Fibrinogen Levels in Hunan Han Population

作　　者：陈英[1,2] 许宏伟[1] 王依宁[1] 李华翔[1] 杨期东[1] 刘运海[1] 

机构地区：[1]中南大学湘雅医院神经内科,湖南长沙市410008 [2]湖南省祁阳县中医院神经内科,湖南省祁阳县426100

出　　处：《中国动脉硬化杂志》2010年第12期985-988,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的观察湖南汉族人群纤维蛋白原β148C/T基因多态性与血浆纤维蛋白原水平和脑梗死的相关性。方法用聚合酶链反应限制片长多态性分析湖南汉族150例脑梗死患者及111例对照者纤维蛋白原β148C/T基因多态性频率分布,并用Clauss法测定血浆纤维蛋白原水平。结果脑梗死组T等位基因频率明显高于对照组（0.325比0.200,P〈0.05）。Logistic回归分析显示,纤维蛋白原β148C/T多态性位点TT基因型是脑梗死的独立危险因素（OR=2.040,95%CI为1.283~3.243,P=0.003）。脑梗死各基因型组血浆纤维蛋白原水平均高于对照组,脑梗死组和对照组TT基因型者血浆纤维蛋白原水平明显高于CC基因型者和CT基因型者（P〈0.05）。结论在湖南汉族人群中,纤维蛋白原β148C/T基因多态性可能与脑梗死易感性有关,TT基因型个体脑梗死发病风险可能增高。纤维蛋白原β148C/T位点多态性可能与血浆纤维蛋白原水平有关,TT基因型个体血浆纤维蛋白原水平较高。Aim To observe the association of fibrinogen β148C/T gene polymorphism with plasma fibrinogen levels and cerebral infarction（CI） in Hunan Han population. Methods 150 subjects with CI and 111 controls were enrolled in the study.The beta fibrinogen site C148T was genotyped by using restriction fragment length polymorphism method.The level of plasma fibrinogen was measured by the Clauss method. Results The frequencies of T allele was 0.325 in CI group,and 0.200 in control group,frequency of T allele was significantly higher in CI group than that in control group（P=0.041）.Furthermore,the results of Logistic regression analysis showed that the genotype of TT was an independent risk factor for CI（OR=2.040,95%CI was 1.283~3.243,P=0.003）.Plasma fibrinogen levels were higher in CI subtypes than those in control subtypes.In both CI group and control group,plasma fibrinogen levels in TT genotype were higher than those in CC and CT genotype. Conclusion Fibrinogen β148C/T polymorphism may be associated with susceptibility to CI in Hunan Han population.TT genotype increased risk to CI.Fibrinogen β148C/T gene polymorphism may have association with plasma fibrinogen level.Carriers of TT genotype at fibrinogen β148C/T gene polymorphism have higher levels of plasma fibrinogen.

关 键 词：纤维蛋白原 基因多态性 脑梗死 

分 类 号：R5[医药卫生—内科学]