动脉血流旋动原理在人造血管研制和血管移植术中的应用  

Clinical application of the swirling flow mechanism in arterial prostheses and bypasses

作　　者：刘肖[1] 孙安强[1] 占帆[1] 陈增胜[1] 邓小燕[1] 

机构地区：[1]北京航空航天大学生物与医学工程学院生物力学与力生物学教育部重点实验室,北京100191

出　　处：《医用生物力学》2010年第5期334-337,共4页Journal of Medical Biomechanics

基　　金：国家自然科学基金资助项目(10632010)

摘　　要：目的将血液流动的旋动流原理用于心血管介入治疗,以期解决小口径人造血管的急性血栓堵塞问题和搭桥手术后下游处血管内膜增生引起的血管再狭窄问题。方法使用计算流体力学(CFD)分别研究具有旋动流特性的新型小口径、S型搭桥和偏心搭桥模型中的流场以及壁面剪切力的分布。同时研究在旋动流下血小板的黏附情况和不同角度的S型搭桥下的血管内膜增生。结果旋动流能明显提高壁面剪切力,抑制血小板的黏附以及血管内膜增生。结论在心血管介入治疗和器械设计中引入旋动流确实可明显改善这些器械中的血流流场,达到抑制小口径人造血管的急性血栓形成和搭桥手术后血管内膜增生的目的。Objective To apply the swirling flow mechanism to the design of arterial prostheses with small diameters and the arterial bypass surgery to resolve the acute thrombus in small diameter prostheses after implantation,and lessen the restenosis of bypassed arteries due to the formation of internal hyperplasia.Method The computational fluid dynamics（CFD） method was used to investigate the flow field and wall shear stress distribution of a new graft,an S-type bypass and an axis deviated arterial bypass,which all had the swirling flow.In addition,the platelet adhesion under swirling flow and internal hyperplasia in S-type bypass were measured.Results The swirling flow can apparently enhance the wall shear stress（WSS） and suppress the platelet adhesion and internal hyperplasia.Conclusions The swirling flow can significantly improve the flow field in arterial graft and bypass to inhibit the acute thrombus in small diameter prostheses and internal hyperplasia after bypass surgery.

关 键 词：旋动流 计算流体力学 剪切力 流场 

分 类 号：R318.01[医药卫生—生物医学工程]