中药天宝肿宁散抗肿瘤细胞生物学作用的研究  

THE EXPERIMENTAL STUDY ON THE ANTITUMOR EFFECT OF “TIAN BAO ZHONG NING SAN”

作　　者：周俊[1] 刘德祥[1] 张月明[1] 闫浩 孙健玲 

机构地区：[1]兰州军区乌鲁木齐总医院临床医学研究所

出　　处：《癌变．畸变．突变》1999年第4期179-183,共5页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：采用体外细胞培养法观察“天宝肿宁散”复方对人膀胱癌细胞（ＥＪ）、人喉癌细胞（Ｈｅｐ２）、人低分化粘液腺胃癌细胞（ＭＧＣ８０３）、人肝癌细胞（Ｑ３）和人肺癌细胞（ＳｐｃＡ１）等肿癌细胞及小鼠成纤维细胞（３Ｔ３）的生物学作用，并观察该方剂对正常小鼠和经环磷酰胺（ＣＰ）处理小鼠的免疫机能、外周血象、造血功能及生存质量的影响。其结果显示该方剂具有一定杀伤肿瘤细胞的作用，并对环磷酰胺（ＣＰ）的毒副作用具有减毒效应。The antitumor effects of Chinese herbs “Tian Bao Zhong Ning San” were studied on cells of fibroblast lines of mouse (3T3), bladder carcinoma cell lines (EJ), throat carcinoma cell lines(IIep 2), stomach carcinoma cell lines(MGC 803), hepatic carcinoma cell lines (Q3) and lung carcinoma cell lines (Spc A 1) with cultured cells in vivo. And the decreasing toxicity effects of the prescription with normal mice and cyclophosphamide (CP) treated mice were also studied. The results showed that “Tian Bao Zhong Ning San” have the effets of antitumor, and cold decrease the toxicity of CP.

关 键 词：中药复方 抗肿瘤 环磷酰胺 

分 类 号：R273.05[医药卫生—中西医结合]