21种中草药抗Trp-P-1的致突变活性  

ANTIMUTAGENIC ACTIVITY ON THE TRP P 1 OF 21 CHINESE MEDICINAL PLANTS

作　　者：吴阿富[1,2,3,4] 吴旻 王伟郎[1,2,3,4] 陈宇峰 朱健儿 

机构地区：[1]浙江医科大学药学院 [2]磐安县人民医院 [3]中科院上海药物所 [4]日本岐阜药科大学

出　　处：《癌变．畸变．突变》1999年第4期198-201,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：本文采用Ａｍｅｓ系统对２１种中草药６０％乙醇提取试样抗３ａｍｉｎｏ１，４ｄｉｍｅｔｈｙｌ５Ｈｐｙｒｉｄｏ［４，３ｂ］ｉｎｄｏｌｅ（ＴｒｐＰ１）致突变活性进行检测。实验结果表明，其中七种中草药：猫人参、黄药子、关木通、山偏柏、半支莲、五加皮、花椒具有较强的抗ＴｒｐＰ１致突变活性。川牛膝、莪术的乙醇提取物没有抗ＴｒｐＰ１致突变活性，但是川牛膝、莪术的水提取物有抗ＴｒｐＰ１的致突变活性。The antimutagenicity of 21 traditional Chinese herbal medicinal plants on Trp P 1 were investigated with Ames bioassay system. It was found that Actinidia valvata Dunn, Dioscorea bulbiffera L., Aristolochia manushuriensis Kom., Selaginell adoederleinii Hieron., Scutellaria revularis Wall., Acanthopanax gracili stylus W.W. Smith. and Zanthoxylum bungeanum Maxim.possessed strong antimutagenic effects. The an timutagenic activity on the Trp P 1 of 60% EtOH extracts from Cythula offcinalis kuan. Curcuma Zedoaria (Berg). Rose had not been found but antimutagenic effects of the aqueous extracts from Cythula officinalis kuan and Curcuma zedoaria(Berg.) Rose. on the Trp P 1 were observed.

关 键 词：抗突变性 中草药 AMES试验 

分 类 号：R285.1[医药卫生—中药学]