“废气不废”:气体信号分子硫化氢的研究进展  

"Waste gas is not waste":advance in the research of hydrogen sulfide

作　　者：金红芳[1] 杜军保[1] 唐朝枢[2] 

机构地区：[1]北京大学第一医院儿科,北京100034 [2]北京大学医学部,北京100191

出　　处：《生理学报》2010年第6期495-504,共10页Acta Physiologica Sinica

基　　金：supported by the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (No.30821001);the Key Grant Project of Chinese Ministry of Education(No.307001);Beijing New Star Project on Science and Technology;China(No.2008A007)

摘　　要：内源性气体信号分子的发现开辟了"废气不废"的新思路。硫化氢(hydrogen sulfide,H2S)是继一氧化氮(nitric oxide,NO)和一氧化碳(carbon monoxide,CO)之后的气体信号分子家系新成员。近年来,人们对H2S的内源性生成、生物学效应及其机制,特别是其在心血管、神经、呼吸、内分泌等系统的疾病发生、发展过程中的病理生理学意义进行了广泛研究。本文综述了近年来H2S相关基础、临床以及药学研究方面的进展,包括H2S对细胞增殖和凋亡、炎症反应、血管新生及离子通道的调节作用,H2S在各种系统疾病发病中的调节作用,H2S供体及其在药学领域的研究进展。The discovery of endogenous gasotransmitters puts forwards a new concept,＂waste gas is not waste＂.Hydrogen sulfide（H2S） is considered as a new member of gasotransmitter family,following nitric oxide（NO） and carbon monoxide（CO）.Recently,the understanding of H2S biological effect and its mechanisms has been deepened,especially the pathophysiological significance of H2S in the various diseases such as cardiovascular diseases,neurological diseases,respiratory diseases,endocrine diseases,etc.This article reviews recent progress of basic,clinical and pharmacological researches related to endogenous H2S,including the regulatory effects of H2S on the cell proliferation,apoptosis,inflammation,angiogenesis and ion channels,the role of endogenous H2S pathway in the pathogenesis of various diseases,as well as the study of the H2S donor and H2S-related drugs.

关 键 词：硫化氢 增殖 凋亡 炎症反应 血管新生 离子通道 

分 类 号：R97[医药卫生—药品]