甲状腺功能正常孕早期妇女TPO抗体阳性对妊娠结局的影响  

Effects of thyroid peroxidase antibody positive on pregnancy outcomes during early euthyroid pregnant women

作　　者：陈冬[1] 邓大同[1] 陈明卫[1] 王红菊[2] 叶志恒[3] 蔡传元[1] 汪珊珊[1] 

机构地区：[1]安徽医科大学第一附属医院内分泌科,安徽合肥230022 [2]安徽医科大学第一附属医院妇产科,安徽合肥230022 [3]安徽医科大学第一附属医院内分泌实验室,安徽合肥230022

出　　处：《中华疾病控制杂志》2011年第4期282-284,共3页Chinese Journal of Disease Control & Prevention

基　　金：安徽省卫生厅自然科学基金(09B104)

摘　　要：目的通过甲状腺过氧化物酶抗体(thyroid peroxidase antibody,TPOAb)的测定,了解其对甲状腺功能正常孕早期妇女妊娠结局的影响。方法本研究选择甲状腺功能正常的孕早期妇女作为研究对象,监测并比较TPOAb阳性和阴性组孕妇在妊娠过程中甲状腺功能的变化特点;比较两组孕妇产科并发症的发生率和分娩后新生儿的临床特征。结果共有251例孕早期妇女纳入本次研究,比较TPOAb阳性和阴性组甲状腺功能紊乱差异有统计学意义(P<0.05),两组产科并发症之间差异有统计学意义(P<0.05),新生儿临床特征差异无统计学意义(P>0.05)。结论 TPOAb阳性孕妇甲状腺功能有向亚临床甲状腺功能减退的趋势。在TPOAb阳性和阴性的孕早期妇女中,产科并发症差异有统计学意义,预示TPOAb阳性对其妊娠结局会有不利影响。Objective To explore effects of thyroid peroxidase antibody on pregnancy outcomes of euthyroid early pregnant women.Methods In this study,TPOAb positive and negative euthyroid early pregnant women were selected as subjects,then the thyroid function changes during pregnancy in the above two groups were compared;the incidence of maternity complications,and neonatal clinical characteristics in newborn babies between two different groups were also compared.Results 251 cases euthyroid pregnant women were enrolled in this study.Thyroid disorders,maternity complications were significantly different（P0.05） between TPOAb positive and negative group,however,neonatal clinical characteristics in newborn babies showed no significant differences（P0.05）.Conclusions TPOAb positive pregnant women have the trend to subclinical hypothyroidism.Maternity complications are significantly different between TPOAb positive and negative group,indicating that TPOAb positive have an adverse effect on pregnancy outcomes.

关 键 词：过氧化物酶类 自身抗体 甲状腺疾病 妊娠并发症 

分 类 号：R581[医药卫生—内分泌]