低分子量肝素对小鼠凝血时间及大鼠静脉血栓形成的影响  

THE EFFECTS OF LOW MOLECULAR WEIGHT HEPARIN ON COAGULATIONTIME OF MICE AND VENOUS THROMBOSIS OF RATS

作　　者：马建[1] 宋艳[1] 李长龄 

机构地区：[1]北京医科大学药学院药理教研室

出　　处：《中国新药杂志》1999年第7期456-458,共3页Chinese Journal of New Drugs

摘　　要：目的：通过观察低分子量肝素（ＬＭＷＨ）对小鼠凝血时间及大鼠静脉血栓形成的影响，对其主要药效学进行了研究，并与国外同类产品Ｃｌｉｖａｒｉｎ及普通肝素进行了比较。方法：玻片法体外测定小鼠全血凝血时间及大鼠体内静脉血栓形成法。结果：ＬＭＷＨｓｃ，４５０，１５０及５０ｕ／ｋｇ可明显延长小鼠全血凝血时间；ｓｃ，１００，３０ｕ／ｋｇ可明显降低大鼠静脉血栓重量。与相同剂量Ｃｌｉｖａｒｉｎ比较，二者药效相当；与普通肝素比较，ＬＭＷＨ有效剂量明显低于普通肝素。结论：ＬＭＷＨ具有生物利用度高、抗栓作用强及对凝血系统影响小的特性。OBJECTIVE :Through observation on its coagulation time in mice and venous thrombosis in rats to study the pharmacodynamics of low molecular weight heparin(LMWH). METHODS :The blood coagulation time in mice and venous thrombosis in rats were used as by in vitro method of glass plate.Imported product,Clivarin,and odinary heparin were used as positive controls.T5HZ]RESULTS :The whole blood coagulation time in mice was signiticantly prolonged by LMWH in dosage of 450,150 u/kg and 50 u/kg by sc administration and the weight of venous thrombosis in rats was significantly reduced by LMWH in dosage of 100 u/kg and 30 u/kg by sc administration.The effect of LMWH was similar to that of imported drug.Clivarin and the effective dose LMWH was significantly lower than that of ordinary heparin sodium. CONCLUSION: LMWH possesses the characteristics of higher bioavailability,stronger antithrombotic effect and fewer side effects on coagulation time when compared with Clivarin and ordinary heparin sodium.

关 键 词：低分子量肝素 凝血时间 静脉血栓形成 药理 

分 类 号：R973.2[医药卫生—药品]