盐酸曲马多缓释片镇痛效果临床评价  

CLINICAL EVALUATION OF THE ANALGESIC EFFECT OF TRAMADOL HCLSUSTAINEDRELEASE TABLETS

作　　者：徐国柱[1,2,3,4,5,6,7,8] 刘锐克 王伟[1,2,3,4,5,6,7,8] 张光健 吴一龙[1,2,3,4,5,6,7,8] 马勇光 胡晓桦[1,2,3,4,5,6,7,8] 鲍继桂[1,2,3,4,5,6,7,8] 李维廉 谢广茹 孙莉 

机构地区：[1]北京医科大学中国药物依赖性研究所 [2]上海医科大学中山医院 [3]中山医科大学第三临床医院 [4]北京医科大学第三临床医学院 [5]广西医科大学肿瘤医院 [6]上海市杨浦区肿瘤防治院 [7]天津市第二中心医院 [8]天津医科大学肿瘤医院

出　　处：《中国新药杂志》1999年第7期471-474,共4页Chinese Journal of New Drugs

摘　　要：目的：评价盐酸曲马多缓释片和盐酸曲马多即刻释放片（普通片）对中度疼痛镇痛效果。方法：随机双盲对照试验为一日给药，用于手术后疼痛，曲马多缓释片１００ｍｇ，ｑ１２ｈｐｏ；普通片５０ｍｇ，ｑ６ｈ，ｐｏ。开放试验为１周给药，用于晚期癌症疼痛患者，曲马多缓释片１００～２００ｍｇ，ｑ１２ｈ，ｐｏ，连用７ｄ。结果：曲马多缓释片与普通片镇痛效果相同，组间无统计学差异。结论：曲马多缓释片对中度疼痛镇痛效果确切。不良反应主要有头晕、嗜睡、胃不适、恶心、呕吐和便秘等。OBJECTIVE :To evaluate clinically the analgesic effect of tramadol HCl in sustainedrelease tablets(SRTH)and immediaterelease tablets(IRTH)in treatment of moderate pain. METHODS :The randomized and double blind tral was conducted in postoperative patients with dose of 100 mg SRTH/12 h or of 50 mg IRTH/6 h.The open trial was conducted in cancer patients with pain using a dose of 100200 mg SRTH/12 h for 1 week. RESULTS :there was no significant difference in analgesic effect between SRTH and IRTH tablets. CONCLUSION :SRTH was effective in treatment of moderate pain and drowsiness,dizziness,stomach discomfort,nausea,vomiting and itching were the ADRs observed.

关 键 词：盐酸曲马多 缓释片 镇痛 药理 

分 类 号：R971.1[医药卫生—药品]